Samba II PCR testing for COVID-19 in pregnant women: a retrospective cohort study and literature review.
BMC Pregnancy Childbirth
; 21(1): 212, 2021 Mar 17.
Article
in English
| MEDLINE | ID: covidwho-1140481
ABSTRACT
BACKGROUND:
Asymptomatic carriage of COVID-19 in pregnant women has been reported and could lead to outbreaks in maternity units. We sought to ascertain the impact of rapid isothernal nucleic acid based testing for COVID-19 in an unselected cohort of pregnant women attending our maternity unit. We also assessed the correlation between community prevalence and asymptomatic carriage.METHODS:
Data for the retrospective cohort study were collected from a large UK tertiary maternity unit over a 4-week period using computerised hospital records. Literature searches were performed across multiple repositories. COVID-19 prevalence was extracted from online repositories.RESULTS:
Nasopharyngeal and oropharyngeal swabs were obtained from 457/465 (98%) women during the study period. The median turnaround time for results was 5.3 h (interquartile range (IQR) 2.6-8.9 h), with 92% of the results returned within 24 h. In our cohort, only one woman tested positive, giving a screen positive rate of 0.22% (1/457; 95% CI 0.04-1.23%). One woman who tested negative developed a fever postnatally following discharge but was lost to follow-up. From our literature review, we did not find any correlation between asymptomatic carriage in pregnant women and the reported regional prevalence of COVID-19.CONCLUSIONS:
Testing using the SAMBA-II machine was acceptable to the vast majority of pregnant women requiring admission and had a low turnaround time. Asymptomatic carriage is low, but not correlated to community prevalence rates. Screening pregnant women on admission will remain an important component in order to minimise nosocomial infection.Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Pregnancy Complications, Infectious
/
Carrier State
/
Cross Infection
/
COVID-19 Nucleic Acid Testing
/
COVID-19
Type of study:
Cohort study
/
Diagnostic study
/
Observational study
/
Prognostic study
/
Randomized controlled trials
/
Reviews
Limits:
Female
/
Humans
/
Pregnancy
Country/Region as subject:
Europa
Language:
English
Journal:
BMC Pregnancy Childbirth
Journal subject:
Obstetrics
Year:
2021
Document Type:
Article
Affiliation country:
S12884-021-03653-4
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