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Analysis of s gene and protein structure difference between porcine coronavirus and SARS-CoV-2
Zhongguo Yufang Shouyi Xuebao / Chinese Journal of Preventive Veterinary Medicine ; 43(1):83-87, 2021.
Article in Chinese | CAB Abstracts | ID: covidwho-1140722
ABSTRACT
The pandemic of COVID-19 (Corona virus disease 2019) caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2) poses a huge threat to human health worldwide since December 2019. In order to study the correlation betweenSARS-CoV-2 and porcine coronavirus, the phylogenetic analysis of spike (S) protein amino acid sequence of human coronavirusand porcine coronavirus, the similarity analysis of the spatial structure of S1 subunit receptor binding domain (RBD) of S proteinwere conducted by bioinformatics analysis, moreover, the double- antigen sandwich ELISA kit was utilized to detect the SARSCoV-2 antibody in common porcine coronavirus positive serum. The results of phylogenetic analysis showed a low identity of Sprotein amino acid sequence between SARS-CoV-2 and porcine coronavirus, indicating a long distance of genetic evolution, andthe S1 subunit RBD spatial structure showed huge differences, meanwhile, all of the porcine coronavirus positive serum samplestested were negative of SARS-CoV-2 antibody. Our data suggested the huge differences in gene and protein level between SARS-CoV-2 and porcine coronavirus, which indicating that SARS-CoV-2 shows a minimal risk of achieving cross-species transmission byinfecting pigs to threaten public health security. This research provides a basis for studying COVID-19 pathogen traceability andbiosafety analysis of cross-species transmission.

Full text: Available Collection: Databases of international organizations Database: CAB Abstracts Language: Chinese Journal: Chinese Journal of Preventive Veterinary Medicine Year: 2021 Document Type: Article

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Full text: Available Collection: Databases of international organizations Database: CAB Abstracts Language: Chinese Journal: Chinese Journal of Preventive Veterinary Medicine Year: 2021 Document Type: Article