Complement cascade in severe forms of COVID-19: Recent advances in therapy.
Eur J Immunol
; 51(7): 1652-1659, 2021 07.
Article
in English
| MEDLINE | ID: covidwho-1141308
ABSTRACT
The complement system is an essential component of the innate immune system. The three complement pathways (classical, lectin, alternative) are directly or indirectly activated by the SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2). In the most severe forms of COVID-19, overactivation of the complement system may contribute to the cytokine storm, endothelial inflammation (endotheliitis) and thrombosis. No antiviral drug has yet been shown to be effective in COVID-19. Therefore, immunotherapies represent a promising therapeutic in the immunopathological phase (following the viral phase) of the disease. Complement blockade, mostly C5a-C5aR axis blockade, may prevent acute respiratory distress syndrome (ARDS) from worsening or progression to death. Clinical trials are underway.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Complement C5a
/
Cytokines
/
Receptor, Anaphylatoxin C5a
/
Cytokine Release Syndrome
/
COVID-19
/
Immunotherapy
Type of study:
Prognostic study
Limits:
Humans
Language:
English
Journal:
Eur J Immunol
Year:
2021
Document Type:
Article
Affiliation country:
Eji.202048959
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