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Association of alpha-1-antitrypsin deficiency with vitamin D status: who is most at risk of getting severe COVID-19?
Shimi, Ghazaleh; Zand, Hamid.
  • Shimi G; Department of Cellular and Molecular Nutrition, Faculty of Nutrition Science and Food Technology, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, 1981619573, Tehran, Iran.
  • Zand H; Department of Cellular and Molecular Nutrition, Faculty of Nutrition Science and Food Technology, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, 1981619573, Tehran, Iran. hamid_zand@sbmu.ac.ir.
Inflamm Res ; 70(4): 375-377, 2021 Apr.
Article in English | MEDLINE | ID: covidwho-1141394
ABSTRACT

INTRODUCTION:

Coronavirus disease 2019 (COVID-19), a new disease that we do not know yet how to treat, is rapidly evolving and has forced us to stay indoors. Surprisingly, a broad range of symptoms has been reported since COVID-19 emergence. Individual variations in susceptibility to SARS-CoV-2 can be due to non-genetic and genetic factors. Alpha-1-antitrypsin deficiency (AATD) is an inherited condition that is associated with an increased risk of liver and lung diseases which may increase susceptibility to COVID-19 infection. At the same time, there could be a possibility of developing non-hereditary AATD.

DISCUSSION:

In addition to some evidence showing the role of vitamin D deficiency in COVID-19 pathology, it has been recognized that there is a biological link between AAT and vitamin D. Therefore, here we offer a new perspective that lower vitamin D levels in COVID-19 patients can cause acquired AATD that provide a condition with more disease severity and a higher risk of death. As a consequence, COVID-19 individuals with vitamin D deficiency may have a higher risk of morbidity and mortality.

CONCLUSION:

Therefore, early vitamin D and AAT assessments and optimal interventions could be helpful to prevent severe COVID-19 outcomes.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Vitamin D / Vitamin D Deficiency / Alpha 1-Antitrypsin Deficiency / COVID-19 Type of study: Prognostic study Topics: Long Covid Limits: Humans Language: English Journal: Inflamm Res Journal subject: Allergy and Immunology / Pathology Year: 2021 Document Type: Article Affiliation country: S00011-021-01456-z

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Vitamin D / Vitamin D Deficiency / Alpha 1-Antitrypsin Deficiency / COVID-19 Type of study: Prognostic study Topics: Long Covid Limits: Humans Language: English Journal: Inflamm Res Journal subject: Allergy and Immunology / Pathology Year: 2021 Document Type: Article Affiliation country: S00011-021-01456-z