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1H, 15N and 13C resonance assignments of the N-terminal domain of the nucleocapsid protein from the endemic human coronavirus HKU1.
de Luna Marques, Aline; Caruso, Icaro Putinhon; Santana-Silva, Marcos Caique; Bezerra, Peter Reis; Araujo, Gabriela Rocha; Almeida, Fabio Ceneviva Lacerda; Amorim, Gisele Cardoso.
  • de Luna Marques A; NUMPEX-BIO, Campus Duque de Caxias, Federal University of Rio de Janeiro (UFRJ), Duque de Caxias, RJ, 25245-390, Brazil.
  • Caruso IP; Institute of Medical Biochemistry Leopoldo de Meis (IBqM) and National Center for Structural Biology and Bioimaging (CENABIO), Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro, RJ, 21941-590, Brazil.
  • Santana-Silva MC; Rio BioNMR Network, Rio de Janeiro, Brazil.
  • Bezerra PR; Institute of Medical Biochemistry Leopoldo de Meis (IBqM) and National Center for Structural Biology and Bioimaging (CENABIO), Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro, RJ, 21941-590, Brazil.
  • Araujo GR; Multiuser Center for Biomolecular Innovation (CMIB) and Department of Physics, Institute of Biosciences, Letters and Exact Sciences (IBILCE), São Paulo State University (UNESP), São José do Rio Preto, SP, 15054-000, Brazil.
  • Almeida FCL; Rio BioNMR Network, Rio de Janeiro, Brazil.
  • Amorim GC; NUMPEX-BIO, Campus Duque de Caxias, Federal University of Rio de Janeiro (UFRJ), Duque de Caxias, RJ, 25245-390, Brazil.
Biomol NMR Assign ; 15(1): 153-157, 2021 04.
Article in English | MEDLINE | ID: covidwho-1141506
Semantic information from SemMedBD (by NLM)
1. Human coronavirus HKU1 LOCATION_OF Measles Virus Nucleoprotein
Subject
Human coronavirus HKU1
Predicate
LOCATION_OF
Object
Measles Virus Nucleoprotein
2. Lung LOCATION_OF Severe disease
Subject
Lung
Predicate
LOCATION_OF
Object
Severe disease
3. Measles Virus Nucleoprotein INTERACTS_WITH Regulatory DNA sequence
Subject
Measles Virus Nucleoprotein
Predicate
INTERACTS_WITH
Object
Regulatory DNA sequence
4. Human coronavirus HKU1 LOCATION_OF Measles Virus Nucleoprotein
Subject
Human coronavirus HKU1
Predicate
LOCATION_OF
Object
Measles Virus Nucleoprotein
5. Lung LOCATION_OF Severe disease
Subject
Lung
Predicate
LOCATION_OF
Object
Severe disease
6. Measles Virus Nucleoprotein INTERACTS_WITH Regulatory DNA sequence
Subject
Measles Virus Nucleoprotein
Predicate
INTERACTS_WITH
Object
Regulatory DNA sequence
ABSTRACT
Coronaviruses have become of great medical and scientific interest because of the Covid-19 pandemic. The hCoV-HKU1 is an endemic betacoronavirus that causes mild respiratory symptoms, although the infection can progress to severe lung disease and death. During viral replication, a discontinuous transcription of the genome takes place, producing the subgenomic messenger RNAs. The nucleocapsid protein (N) plays a pivotal role in the regulation of this process, acting as an RNA chaperone and participating in the nucleocapsid assembly. The isolated N-terminal domain of protein N (N-NTD) specifically binds to the transcriptional regulatory sequences and control the melting of the double-stranded RNA. Here, we report the resonance assignments of the N-NTD of HKU1-CoV.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: Magnetic Resonance Spectroscopy / Betacoronavirus / Coronavirus Nucleocapsid Proteins Language: English Journal: Biomol NMR Assign Journal subject: Molecular Biology / Nuclear Medicine Year: 2021 Document Type: Article Affiliation country: S12104-020-09998-9

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Magnetic Resonance Spectroscopy / Betacoronavirus / Coronavirus Nucleocapsid Proteins Language: English Journal: Biomol NMR Assign Journal subject: Molecular Biology / Nuclear Medicine Year: 2021 Document Type: Article Affiliation country: S12104-020-09998-9