Your browser doesn't support javascript.
Infection- and vaccine-induced antibody binding and neutralization of the B.1.351 SARS-CoV-2 variant.
Edara, Venkata Viswanadh; Norwood, Carson; Floyd, Katharine; Lai, Lilin; Davis-Gardner, Meredith E; Hudson, William H; Mantus, Grace; Nyhoff, Lindsay E; Adelman, Max W; Fineman, Rebecca; Patel, Shivan; Byram, Rebecca; Gomes, Dumingu Nipuni; Michael, Garett; Abdullahi, Hayatu; Beydoun, Nour; Panganiban, Bernadine; McNair, Nina; Hellmeister, Kieffer; Pitts, Jamila; Winters, Joy; Kleinhenz, Jennifer; Usher, Jacob; O'Keefe, James B; Piantadosi, Anne; Waggoner, Jesse J; Babiker, Ahmed; Stephens, David S; Anderson, Evan J; Edupuganti, Srilatha; Rouphael, Nadine; Ahmed, Rafi; Wrammert, Jens; Suthar, Mehul S.
  • Edara VV; Center for Childhood Infections and Vaccines of Children's Healthcare of Atlanta, Department of Pediatrics, Emory University School of Medicine, Atlanta, GA 30322, USA; Emory Vaccine Center, Emory University, Atlanta, GA 30322, USA; Yerkes National Primate Research Center, Atlanta, GA 30329, USA.
  • Norwood C; Center for Childhood Infections and Vaccines of Children's Healthcare of Atlanta, Department of Pediatrics, Emory University School of Medicine, Atlanta, GA 30322, USA; Emory Vaccine Center, Emory University, Atlanta, GA 30322, USA; Department of Medicine, Emory University School of Medicine, Atlant
  • Floyd K; Center for Childhood Infections and Vaccines of Children's Healthcare of Atlanta, Department of Pediatrics, Emory University School of Medicine, Atlanta, GA 30322, USA; Emory Vaccine Center, Emory University, Atlanta, GA 30322, USA; Yerkes National Primate Research Center, Atlanta, GA 30329, USA.
  • Lai L; Center for Childhood Infections and Vaccines of Children's Healthcare of Atlanta, Department of Pediatrics, Emory University School of Medicine, Atlanta, GA 30322, USA; Emory Vaccine Center, Emory University, Atlanta, GA 30322, USA; Yerkes National Primate Research Center, Atlanta, GA 30329, USA.
  • Davis-Gardner ME; Center for Childhood Infections and Vaccines of Children's Healthcare of Atlanta, Department of Pediatrics, Emory University School of Medicine, Atlanta, GA 30322, USA; Emory Vaccine Center, Emory University, Atlanta, GA 30322, USA; Yerkes National Primate Research Center, Atlanta, GA 30329, USA.
  • Hudson WH; Department of Microbiology and Immunology, Emory University, Atlanta, GA 30322, USA.
  • Mantus G; Center for Childhood Infections and Vaccines of Children's Healthcare of Atlanta, Department of Pediatrics, Emory University School of Medicine, Atlanta, GA 30322, USA; Emory Vaccine Center, Emory University, Atlanta, GA 30322, USA; Department of Medicine, Emory University School of Medicine, Atlant
  • Nyhoff LE; Center for Childhood Infections and Vaccines of Children's Healthcare of Atlanta, Department of Pediatrics, Emory University School of Medicine, Atlanta, GA 30322, USA; Emory Vaccine Center, Emory University, Atlanta, GA 30322, USA; Department of Medicine, Emory University School of Medicine, Atlant
  • Adelman MW; Department of Medicine, Emory University School of Medicine, Atlanta, GA 30329, USA.
  • Fineman R; Department of Medicine, Emory University School of Medicine, Atlanta, GA 30329, USA.
  • Patel S; Department of Medicine, Emory University School of Medicine, Atlanta, GA 30329, USA.
  • Byram R; Department of Medicine, Emory University School of Medicine, Atlanta, GA 30329, USA.
  • Gomes DN; Department of Medicine, Emory University School of Medicine, Atlanta, GA 30329, USA.
  • Michael G; Department of Medicine, Emory University School of Medicine, Atlanta, GA 30329, USA.
  • Abdullahi H; Department of Medicine, Emory University School of Medicine, Atlanta, GA 30329, USA.
  • Beydoun N; Department of Medicine, Emory University School of Medicine, Atlanta, GA 30329, USA.
  • Panganiban B; Department of Medicine, Emory University School of Medicine, Atlanta, GA 30329, USA.
  • McNair N; Department of Medicine, Emory University School of Medicine, Atlanta, GA 30329, USA.
  • Hellmeister K; Department of Medicine, Emory University School of Medicine, Atlanta, GA 30329, USA.
  • Pitts J; Department of Medicine, Emory University School of Medicine, Atlanta, GA 30329, USA.
  • Winters J; Department of Medicine, Emory University School of Medicine, Atlanta, GA 30329, USA.
  • Kleinhenz J; Department of Medicine, Emory University School of Medicine, Atlanta, GA 30329, USA.
  • Usher J; Department of Medicine, Emory University School of Medicine, Atlanta, GA 30329, USA.
  • O'Keefe JB; Department of Medicine, Emory University School of Medicine, Atlanta, GA 30329, USA.
  • Piantadosi A; Department of Medicine, Emory University School of Medicine, Atlanta, GA 30329, USA; Department of Pathology and Laboratory Medicine, Emory University School of Medicine Atlanta, Georgia, USA.
  • Waggoner JJ; Department of Medicine, Emory University School of Medicine, Atlanta, GA 30329, USA.
  • Babiker A; Department of Medicine, Emory University School of Medicine, Atlanta, GA 30329, USA; Department of Pathology and Laboratory Medicine, Emory University School of Medicine Atlanta, Georgia, USA.
  • Stephens DS; Emory Vaccine Center, Emory University, Atlanta, GA 30322, USA; Department of Medicine, Emory University School of Medicine, Atlanta, GA 30329, USA.
  • Anderson EJ; Center for Childhood Infections and Vaccines of Children's Healthcare of Atlanta, Department of Pediatrics, Emory University School of Medicine, Atlanta, GA 30322, USA.
  • Edupuganti S; Department of Medicine, Emory University School of Medicine, Atlanta, GA 30329, USA; Hope Clinic of Emory Vaccine Center, Emory University, Decatur, GA 30030, USA.
  • Rouphael N; Department of Medicine, Emory University School of Medicine, Atlanta, GA 30329, USA; Hope Clinic of Emory Vaccine Center, Emory University, Decatur, GA 30030, USA.
  • Ahmed R; Emory Vaccine Center, Emory University, Atlanta, GA 30322, USA; Department of Microbiology and Immunology, Emory University, Atlanta, GA 30322, USA.
  • Wrammert J; Center for Childhood Infections and Vaccines of Children's Healthcare of Atlanta, Department of Pediatrics, Emory University School of Medicine, Atlanta, GA 30322, USA; Emory Vaccine Center, Emory University, Atlanta, GA 30322, USA. Electronic address: jwramme@emory.edu.
  • Suthar MS; Center for Childhood Infections and Vaccines of Children's Healthcare of Atlanta, Department of Pediatrics, Emory University School of Medicine, Atlanta, GA 30322, USA; Emory Vaccine Center, Emory University, Atlanta, GA 30322, USA; Department of Microbiology and Immunology, Emory University, Atlant
Cell Host Microbe ; 29(4): 516-521.e3, 2021 04 14.
Article in English | MEDLINE | ID: covidwho-1141671
ABSTRACT
The emergence of SARS-CoV-2 variants with mutations in the spike protein is raising concerns about the efficacy of infection- or vaccine-induced antibodies. We compared antibody binding and live virus neutralization of sera from naturally infected and Moderna-vaccinated individuals against two SARS-CoV-2 variants B.1 containing the spike mutation D614G and the emerging B.1.351 variant containing additional spike mutations and deletions. Sera from acutely infected and convalescent COVID-19 patients exhibited a 3-fold reduction in binding antibody titers to the B.1.351 variant receptor-binding domain of the spike protein and a 3.5-fold reduction in neutralizing antibody titers against SARS-CoV-2 B.1.351 variant compared to the B.1 variant. Similar results were seen with sera from Moderna-vaccinated individuals. Despite reduced antibody titers against the B.1.351 variant, sera from infected and vaccinated individuals containing polyclonal antibodies to the spike protein could still neutralize SARS-CoV-2 B.1.351, suggesting that protective humoral immunity may be retained against this variant.
Subject(s)
Keywords
Fulltext
Print
XML
PubMed Links
Search on Google

Full text: Available Collection: International databases Database: MEDLINE Main subject: Antibodies, Neutralizing / COVID-19 Vaccines / SARS-CoV-2 / COVID-19 / Antibodies, Viral Topics: Vaccines / Variants Limits: Humans Language: English Journal: Cell Host Microbe Journal subject: Microbiology Year: 2021 Document Type: Article Affiliation country: J.chom.2021.03.009

Similar

MEDLINE
LILACS
LIS
Fulltext
Print
XML
PubMed Links
Search on Google

Full text: Available Collection: International databases Database: MEDLINE Main subject: Antibodies, Neutralizing / COVID-19 Vaccines / SARS-CoV-2 / COVID-19 / Antibodies, Viral Topics: Vaccines / Variants Limits: Humans Language: English Journal: Cell Host Microbe Journal subject: Microbiology Year: 2021 Document Type: Article Affiliation country: J.chom.2021.03.009