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Serological surveillance of SARS-CoV-2: Six-month trends and antibody response in a cohort of public health workers.
Harris, Ross J; Whitaker, Heather J; Andrews, Nick J; Aiano, Felicity; Amin-Chowdhury, Zahin; Flood, Jessica; Borrow, Ray; Linley, Ezra; Ahmad, Shazaad; Stapley, Lorraine; Hallis, Bassam; Amirthalingam, Gayatri; Höschler, Katja; Parker, Ben; Horsley, Alex; Brooks, Timothy J G; Brown, Kevin E; Ramsay, Mary E; Ladhani, Shamez N.
  • Harris RJ; Statistics, Modelling and Economics Department, Public Health England Colindale, National Infection Service, 61 Colindale Avenue, London NW9 5EQ, UK.
  • Whitaker HJ; Statistics, Modelling and Economics Department, Public Health England Colindale, National Infection Service, 61 Colindale Avenue, London NW9 5EQ, UK.
  • Andrews NJ; Statistics, Modelling and Economics Department, Public Health England Colindale, National Infection Service, 61 Colindale Avenue, London NW9 5EQ, UK.
  • Aiano F; Immunisation and Countermeasures Division, PHE Colindale, National Infection Service, 61 Colindale Avenue, London NW9 5EQ, UK.
  • Amin-Chowdhury Z; Immunisation and Countermeasures Division, PHE Colindale, National Infection Service, 61 Colindale Avenue, London NW9 5EQ, UK.
  • Flood J; Immunisation and Countermeasures Division, PHE Colindale, National Infection Service, 61 Colindale Avenue, London NW9 5EQ, UK.
  • Borrow R; Sero-epidemiology Unit, Public Health England, Public Health Laboratory Manchester, Manchester Medical Microbiology Partnership, Manchester Royal Infirmary, Oxford Road, Manchester M13 9WL, UK.
  • Linley E; Sero-epidemiology Unit, Public Health England, Public Health Laboratory Manchester, Manchester Medical Microbiology Partnership, Manchester Royal Infirmary, Oxford Road, Manchester M13 9WL, UK.
  • Ahmad S; Manchester University NHS Foundation Trust, UK.
  • Stapley L; Immunoassay Lab, National Infection Service, Porton Down, SP4 0JG, UK.
  • Hallis B; Immunoassay Lab, National Infection Service, Porton Down, SP4 0JG, UK.
  • Amirthalingam G; Immunisation and Countermeasures Division, PHE Colindale, National Infection Service, 61 Colindale Avenue, London NW9 5EQ, UK.
  • Höschler K; Virus Reference Department, Reference Microbiology, Public Health England Colindale, National Infection Service, 61 Colindale Avenue, London NW9 5EQ, UK.
  • Parker B; NIHR Manchester Clinical Research Facility, Manchester University NHS Foundation Trust, Manchester M13 9WL, UK; Kellgren Centre for Rheumatology, NIHR Manchester Biomedical Research Centre, Manchester University NHS Foundation Trust, Manchester M13 9WL, UK.
  • Horsley A; Division of Infection, Inflammation and Respiratory Medicine, University of Manchester, Manchester M23 9LT, UK.
  • Brooks TJG; Rare & Imported Pathogens Laboratory, Public Health England, Manor Farm Road, Porton Down, Salisbury SO4 0JG, UK.
  • Brown KE; Immunisation and Countermeasures Division, PHE Colindale, National Infection Service, 61 Colindale Avenue, London NW9 5EQ, UK.
  • Ramsay ME; Immunisation and Countermeasures Division, PHE Colindale, National Infection Service, 61 Colindale Avenue, London NW9 5EQ, UK.
  • Ladhani SN; Immunisation and Countermeasures Division, PHE Colindale, National Infection Service, 61 Colindale Avenue, London NW9 5EQ, UK; Paediatric Infectious Diseases Research Group (PIDRG), St. Georges University of London (SGUL), London, UK. Electronic address: Shamez.Ladhani@phe.gov.uk.
J Infect ; 82(5): 162-169, 2021 05.
Article in English | MEDLINE | ID: covidwho-1142042
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Semantic information from SemMedBD (by NLM)
1. Antibody Formation PROCESS_OF Cohort
Subject
Antibody Formation
Predicate
PROCESS_OF
Object
Cohort
2. Antibodies PART_OF 2019 novel coronavirus
Subject
Antibodies
Predicate
PART_OF
Object
2019 novel coronavirus
3. Antibody Formation PROCESS_OF Cohort
Subject
Antibody Formation
Predicate
PROCESS_OF
Object
Cohort
4. Antibodies PART_OF 2019 novel coronavirus
Subject
Antibodies
Predicate
PART_OF
Object
2019 novel coronavirus
ABSTRACT

BACKGROUND:

Antibody waning after SARS-CoV-2 infection may result in reduction in long-term immunity following natural infection and vaccination, and is therefore a major public health issue. We undertook prospective serosurveillance in a large cohort of healthy adults from the start of the epidemic in England.

METHODS:

Clinical and non-clinical healthcare workers were recruited across three English regions and tested monthly from March to November 2020 for SARS-CoV-2 spike (S) protein and nucleoprotein (N) antibodies using five different immunoassays. In positive individuals, antibody responses and long-term trends were modelled using mixed effects regression.

FINDINGS:

In total, 2246 individuals attended 12,247 visits and 264 were seropositive in ≥ 2 assays. Most seroconversions occurred between March and April 2020. The assays showed > 85% agreement for ever-positivity, although this changed markedly over time. Antibodies were detected earlier with Abbott (N) but declined rapidly thereafter. With the EuroImmun (S) and receptor-binding domain (RBD) assays, responses increased for 4 weeks then fell until week 12-16 before stabilising. For Roche (N), responses increased until 8 weeks, stabilised, then declined, but most remained above the positive threshold. For Roche (S), responses continued to climb over the full 24 weeks, with no sero-reversions. Predicted proportions sero-reverting after 52 weeks were 100% for Abbott, 59% (95% credible interval 50-68%) Euroimmun, 41% (30-52%) RBD, 10% (8-14%) Roche (N) < 2% Roche (S).

INTERPRETATION:

Trends in SARS-CoV-2 antibodies following infection are highly dependent on the assay used. Ongoing serosurveillance using multiple assays is critical for monitoring the course and long-term progression of SARS-CoV-2 antibodies.
Subject(s)

Full text: Available Collection: International databases Database: MEDLINE Main subject: SARS-CoV-2 / COVID-19 Type of study: Observational study / Prognostic study / Risk factors / Screening study Limits: Adult / Humans Country/Region as subject: Europa Language: English Journal: J Infect Year: 2021 Document Type: Article Affiliation country: J.jinf.2021.03.015

Full text: Available Collection: International databases Database: MEDLINE Main subject: SARS-CoV-2 / COVID-19 Type of study: Observational study / Prognostic study / Risk factors / Screening study Limits: Adult / Humans Country/Region as subject: Europa Language: English Journal: J Infect Year: 2021 Document Type: Article Affiliation country: J.jinf.2021.03.015