Insights into the mechanisms of Th17 differentiation and the Yin-Yang of Th17 cells in human diseases.
Mol Immunol
; 134: 109-117, 2021 06.
Article
in English
| MEDLINE | ID: covidwho-1142153
ABSTRACT
Th17 cells are a lineage of CD4+ T helper cells with Th17-specific transcription factors RORγt and RoRα. Since its discovery in 2005, research on Th17 has been in rapid progress, and increasing cytokines or transcription factors have been uncovered in the activation and differentiation of Th17 cells. Furthermore, growing evidence proves there are two different subsets of Th17 cells, namely non-pathogenic Th17 (non-pTh17) and pathogenic Th17 (pTh17), both of which play important roles in adaptive immunity, especially in host defenses, autoimmune diseases, and cancer. In this review, we summarize and discuss the mechanisms of Th17 cells differentiation, and their roles in immunity and diseases.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Cell Differentiation
/
Th17 Cells
Limits:
Humans
Language:
English
Journal:
Mol Immunol
Year:
2021
Document Type:
Article
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