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COVID-19 and emerging spinal cord complications: A systematic review.
Mondal, Ritwick; Deb, Shramana; Shome, Gourav; Ganguly, Upasana; Lahiri, Durjoy; Benito-León, Julián.
  • Mondal R; Institute of Post Graduate Medical Education and Research, SSKM Hospital, Kolkata, India.
  • Deb S; S.N. Pradhan Centre for Neuroscience, University of Calcutta, Kolkata, India.
  • Shome G; Department of Microbiology, University of Calcutta, Kolkata, India.
  • Ganguly U; Institute of Post Graduate Medical Education and Research, SSKM Hospital, Kolkata, India.
  • Lahiri D; Institute of Post Graduate Medical Education and Research, SSKM Hospital, Kolkata, India; R.G. Kar Medical College and Hospital, Kolkata, India. Electronic address: dlahiri1988@gmail.com.
  • Benito-León J; Department of Neurology, University Hospital "12 de Octubre",Madrid, Spain; Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain; Department of Medicine, Complutense University, Madrid, Spain. Electronic address: jbenitol67@gmail.com.
Mult Scler Relat Disord ; 51: 102917, 2021 Jun.
Article in English | MEDLINE | ID: covidwho-1142159
ABSTRACT

BACKGROUND:

Spinal cord complications associated with coronavirus infectious disease of 2019 (COVID-19) are being widely reported. The purpose of this systematic review was to summarize so far available pieces of evidence documenting de novo novel severe acute respiratory syndrome coronavirus (SARS-CoV-2) mediated spinal cord demyelinating diseases. Indeed, the spinal demyelinating disorders that have been reported in those patients who have suffered from COVID-19 rather than on the people already living with diagnosed or undiagnosed primary demyelinating disorders.

METHODS:

We used the existing PRISMA consensus statement. Data were collected from PubMed, NIH Litcovid, EMBASE and Cochrane library databases, as well as Pre-print servers (medRxiv, bioRxiv, and pre-preints.org), until September 10, 2020, using pre-specified searching strategies.

RESULTS:

The 21 selected articles were all case reports and included 11 (52%) men and 10 (48%) women. The mean age was of 46.7 ±â€¯18.0. The neurological manifestations included weakness, sensory deficit, autonomic dysfunction and ataxia. In most cases, elevated cerebrospinal fluid protein as well as lymphocytic pleocytosis were found. SARS-CoV-2 was detected in five (24%) patients, meanwhile in 13 (62%) patients, the testing was negative. Testing was not performed in two cases and, in one, data were unavailable. Nearly half of the cases (N = 9) were associated with isolated long extensive transverse myelitis (LETM), whereas a combination of both LETM and patchy involvement was found in two. Only five patients had isolated short segment involvement and two patchy involvement. Furthermore, concomitant demyelination of both brain and spine was reported in six patients. Concerning the prognosis, most of the patients improved and the mortality rate was low (N = 2, <10%).

CONCLUSION:

Spinal cord demyelination should be added to the plethora of immune mediated neurologic complications associated with COVID-19.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Communicable Diseases / COVID-19 / Nervous System Diseases Type of study: Prognostic study / Reviews / Systematic review/Meta Analysis Limits: Female / Humans / Male Language: English Journal: Mult Scler Relat Disord Year: 2021 Document Type: Article Affiliation country: J.msard.2021.102917

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Communicable Diseases / COVID-19 / Nervous System Diseases Type of study: Prognostic study / Reviews / Systematic review/Meta Analysis Limits: Female / Humans / Male Language: English Journal: Mult Scler Relat Disord Year: 2021 Document Type: Article Affiliation country: J.msard.2021.102917