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Phylogenomic tracing of asymptomatic transmission in a COVID-19 outbreak.
Zhang, Ju; Ding, Nan; Song, Yangzi; Song, Rui; Pan, Yang; Wang, Linghang; Yan, Shuo; Wang, Qi; Ma, Shanfang; Wei, Lirong; Yu, Fengting; Lu, Lianhe; Zhang, Fujie; Chen, Chen; Zeng, Hui.
  • Zhang J; Beijing Ditan Hospital, Capital Medical University, Beijing 100015, China.
  • Ding N; Beijing Key Laboratory of Emerging Infectious Diseases, Beijing 100015, China.
  • Song Y; Beijing Ditan Hospital, Capital Medical University, Beijing 100015, China.
  • Song R; Beijing Key Laboratory of Emerging Infectious Diseases, Beijing 100015, China.
  • Pan Y; Beijing Ditan Hospital, Capital Medical University, Beijing 100015, China.
  • Wang L; Beijing Key Laboratory of Emerging Infectious Diseases, Beijing 100015, China.
  • Yan S; Beijing Ditan Hospital, Capital Medical University, Beijing 100015, China.
  • Wang Q; Institute for Infectious Disease and Endemic Disease Control, Beijing Center for Disease Prevention and Control, Beijing 100013, China.
  • Ma S; Beijing Ditan Hospital, Capital Medical University, Beijing 100015, China.
  • Wei L; Beijing Key Laboratory of Emerging Infectious Diseases, Beijing 100015, China.
  • Yu F; Beijing Ditan Hospital, Capital Medical University, Beijing 100015, China.
  • Lu L; Beijing Ditan Hospital, Capital Medical University, Beijing 100015, China.
  • Zhang F; Beijing Ditan Hospital, Capital Medical University, Beijing 100015, China.
  • Chen C; Beijing Ditan Hospital, Capital Medical University, Beijing 100015, China.
  • Zeng H; Beijing Ditan Hospital, Capital Medical University, Beijing 100015, China.
Innovation (Camb) ; 2(2): 100099, 2021 May 28.
Article in English | MEDLINE | ID: covidwho-1142304
ABSTRACT
SARS-CoV-2 has caused over 100 million deaths and continues to spread rapidly around the world. Asymptomatic transmission of SARS-CoV-2 is the Achilles' heel of COVID-19 public health control measures. Phylogenomic data on SARS-CoV-2 could provide more direct information about asymptomatic transmission. In this study, using a novel MINERVA sequencing technology, we traced asymptomatic transmission of COVID-19 patients in Beijing, China. One hundred and seventy-eight close contacts were quarantined, and 14 COVID-19 patients were laboratory confirmed by RT-PCR. We provide direct phylogenomic evidence of asymptomatic transmission by constructing the median joining network in the cluster. These data could help us to determine whether the current symptom-based screening should cover asymptomatic persons.
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Full text: Available Collection: International databases Database: MEDLINE Language: English Journal: Innovation (Camb) Year: 2021 Document Type: Article Affiliation country: J.xinn.2021.100099

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Full text: Available Collection: International databases Database: MEDLINE Language: English Journal: Innovation (Camb) Year: 2021 Document Type: Article Affiliation country: J.xinn.2021.100099