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Covid-19 and gender: lower rate but same mortality of severe disease in women-an observational study.
Raimondi, Federico; Novelli, Luca; Ghirardi, Arianna; Russo, Filippo Maria; Pellegrini, Dario; Biza, Roberta; Trapasso, Roberta; Giuliani, Lisa; Anelli, Marisa; Amoroso, Mariangela; Allegri, Chiara; Imeri, Gianluca; Sanfilippo, Claudia; Comandini, Sofia; Hila, England; Manesso, Leonardo; Gandini, Lucia; Mandelli, Pietro; Monti, Martina; Gori, Mauro; Senni, Michele; Lorini, Ferdinando Luca; Rizzi, Marco; Barbui, Tiziano; Paris, Laura; Rambaldi, Alessandro; Cosentini, Roberto; Guagliumi, Giulio; Cesa, Simonetta; Colledan, Michele; Sessa, Maria; Masciulli, Arianna; Gavazzi, Antonello; Buoro, Sabrina; Remuzzi, Giuseppe; Ruggenenti, Piero; Callegaro, Annapaola; Gianatti, Andrea; Farina, Claudio; Bellasi, Antonio; Sironi, Sandro; Fagiuoli, Stefano; Di Marco, Fabiano.
  • Raimondi F; Pulmonary Medicine Unit, Medicine Department, ASST Papa Giovanni XXIII, Piazza OMS, 1, 24127, Bergamo, Italy.
  • Novelli L; Università degli Studi di Milano, Milan, Italy.
  • Ghirardi A; Pulmonary Medicine Unit, Medicine Department, ASST Papa Giovanni XXIII, Piazza OMS, 1, 24127, Bergamo, Italy.
  • Russo FM; FROM Research Foundation, Bergamo, Italy.
  • Pellegrini D; Università degli Studi di Milano, Milan, Italy.
  • Biza R; Intensive Care Unit, ASST Papa Giovanni XXIII, Bergamo, Italy.
  • Trapasso R; Cardiovascular Department, ASST Papa Giovanni XXIII, Bergamo, Italy.
  • Giuliani L; Pulmonary Medicine Unit, Medicine Department, ASST Papa Giovanni XXIII, Piazza OMS, 1, 24127, Bergamo, Italy.
  • Anelli M; Università degli Studi di Milano, Milan, Italy.
  • Amoroso M; Pulmonary Medicine Unit, Medicine Department, ASST Papa Giovanni XXIII, Piazza OMS, 1, 24127, Bergamo, Italy.
  • Allegri C; Università degli Studi di Milano, Milan, Italy.
  • Imeri G; Pulmonary Medicine Unit, Medicine Department, ASST Papa Giovanni XXIII, Piazza OMS, 1, 24127, Bergamo, Italy.
  • Sanfilippo C; Università degli Studi di Milano, Milan, Italy.
  • Comandini S; Pulmonary Medicine Unit, Medicine Department, ASST Papa Giovanni XXIII, Piazza OMS, 1, 24127, Bergamo, Italy.
  • Hila E; Università degli Studi di Milano, Milan, Italy.
  • Manesso L; Pulmonary Medicine Unit, Medicine Department, ASST Papa Giovanni XXIII, Piazza OMS, 1, 24127, Bergamo, Italy.
  • Gandini L; Università degli Studi di Milano, Milan, Italy.
  • Mandelli P; Pulmonary Medicine Unit, Medicine Department, ASST Papa Giovanni XXIII, Piazza OMS, 1, 24127, Bergamo, Italy.
  • Monti M; Università degli Studi di Milano, Milan, Italy.
  • Gori M; Pulmonary Medicine Unit, Medicine Department, ASST Papa Giovanni XXIII, Piazza OMS, 1, 24127, Bergamo, Italy.
  • Senni M; Pulmonary Medicine Unit, Medicine Department, ASST Papa Giovanni XXIII, Piazza OMS, 1, 24127, Bergamo, Italy.
  • Lorini FL; Pulmonary Medicine Unit, Medicine Department, ASST Papa Giovanni XXIII, Piazza OMS, 1, 24127, Bergamo, Italy.
  • Rizzi M; Università degli Studi di Milano, Milan, Italy.
  • Barbui T; Intensive Care Unit, ASST Papa Giovanni XXIII, Bergamo, Italy.
  • Paris L; Università degli Studi di Milano, Milan, Italy.
  • Rambaldi A; Intensive Care Unit, ASST Papa Giovanni XXIII, Bergamo, Italy.
  • Cosentini R; Università degli Studi di Milano, Milan, Italy.
  • Guagliumi G; Intensive Care Unit, ASST Papa Giovanni XXIII, Bergamo, Italy.
  • Cesa S; Università degli Studi di Milano, Milan, Italy.
  • Colledan M; Intensive Care Unit, ASST Papa Giovanni XXIII, Bergamo, Italy.
  • Sessa M; Università degli Studi di Milano, Milan, Italy.
  • Masciulli A; Intensive Care Unit, ASST Papa Giovanni XXIII, Bergamo, Italy.
  • Gavazzi A; Cardiovascular Department, ASST Papa Giovanni XXIII, Bergamo, Italy.
  • Buoro S; Cardiovascular Department, ASST Papa Giovanni XXIII, Bergamo, Italy.
  • Remuzzi G; Intensive Care Unit, ASST Papa Giovanni XXIII, Bergamo, Italy.
  • Ruggenenti P; Infectious Diseases Unit, ASST Papa Giovanni XXIII, Bergamo, Italy.
  • Callegaro A; FROM Research Foundation, Bergamo, Italy.
  • Gianatti A; Department of Oncology and Hematology, ASST Papa Giovanni XXIII, Bergamo, Italy.
  • Farina C; Università degli Studi di Milano, Milan, Italy.
  • Bellasi A; Department of Oncology and Hematology, ASST Papa Giovanni XXIII, Bergamo, Italy.
  • Sironi S; Emergency Department, ASST Papa Giovanni XXIII, Bergamo, Italy.
  • Fagiuoli S; Cardiovascular Department, ASST Papa Giovanni XXIII, Bergamo, Italy.
  • Di Marco F; Department of Organ Failure and Transplantation, ASST Papa Giovanni XXIII, Bergamo, Italy.
BMC Pulm Med ; 21(1): 96, 2021 Mar 20.
Article in English | MEDLINE | ID: covidwho-1143203
ABSTRACT

BACKGROUND:

Gender-related factors might affect vulnerability to Covid-19. The aim of this study was to describe the role of gender on clinical features and 28-day mortality in Covid-19 patients.

METHODS:

Observational study of Covid-19 patients hospitalized in Bergamo, Italy, during the first three weeks of the outbreak. Medical records, clinical, radiological and laboratory findings upon admission and treatment have been collected. Primary outcome was 28-day mortality since hospitalization.

RESULTS:

431 consecutive adult patients were admitted. Female patients were 119 (27.6%) with a mean age of 67.0 ± 14.5 years (vs 67.8 ± 12.5 for males, p = 0.54). Previous history of myocardial infarction, vasculopathy and former smoking habits were more common for males. At the time of admission PaO2/FiO2 was similar between men and women (228 [IQR, 134-273] vs 238 mmHg [150-281], p = 0.28). Continuous Positive Airway Pressure (CPAP) assistance was needed in the first 24 h more frequently in male patients (25.7% vs 13.0%; p = 0.006). Overall 28-day mortality was 26.1% in women and 38.1% in men (p = 0.018). Gender did not result an independent predictor of death once the parameters related to disease severity at presentation were included in the multivariable analysis (p = 0.898). Accordingly, the Kaplan-Meier survival analysis in female and male patients requiring CPAP or non-invasive ventilation in the first 24 h did not find a significant difference (p = 0.687).

CONCLUSION:

Hospitalized women are less likely to die from Covid-19; however, once severe disease occurs, the risk of dying is similar to men. Further studies are needed to better investigate the role of gender in clinical course and outcome of Covid-19.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Type of study: Observational study / Prognostic study Limits: Aged / Female / Humans / Male / Middle aged Country/Region as subject: Europa Language: English Journal: BMC Pulm Med Year: 2021 Document Type: Article Affiliation country: S12890-021-01455-0

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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Type of study: Observational study / Prognostic study Limits: Aged / Female / Humans / Male / Middle aged Country/Region as subject: Europa Language: English Journal: BMC Pulm Med Year: 2021 Document Type: Article Affiliation country: S12890-021-01455-0