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Lung Ultrasound Patterns and Clinical-Laboratory Correlates during COVID-19 Pneumonia: A Retrospective Study from North East Italy.
Senter, Riccardo; Capone, Federico; Pasqualin, Stefano; Cerruti, Lorenzo; Molinari, Leonardo; Fonte Basso, Elisa; Zanforlin, Nicolò; Previato, Lorenzo; Toffolon, Alessandro; Sensi, Caterina; Arcidiacono, Gaetano; Gorgi, Davide; Ippolito, Renato; Nessi, Enrico; Pettenella, Pietro; Cellini, Andrea; Fossa, Claudio; Vania, Eleonora; Gardin, Samuele; Sukthi, Andi; Luise, Dora; Giordani, Maria Teresa; Zanatta, Mirko; Savino, Sandro; Cianci, Vito; Sattin, Andrea; Maria, Anna; Vianello, Andrea; Pesavento, Raffaele; Giannini, Sandro; Avogaro, Angelo; Vettor, Roberto; Fadini, Gian Paolo; Saller, Alois.
  • Senter R; Department of Medicine, University of Padova, Via VIII Febbraio, 2, 35122 Padova, Italy.
  • Capone F; Department of Medicine, University of Padova, Via VIII Febbraio, 2, 35122 Padova, Italy.
  • Pasqualin S; Department of Emergency, University Hospital of Padova, Via Giustiniani, 2, 35128 Padova, Italy.
  • Cerruti L; Department of Medicine, University of Padova, Via VIII Febbraio, 2, 35122 Padova, Italy.
  • Molinari L; Department of Medicine, University of Padova, Via VIII Febbraio, 2, 35122 Padova, Italy.
  • Fonte Basso E; Department of Emergency, University Hospital of Padova, Via Giustiniani, 2, 35128 Padova, Italy.
  • Zanforlin N; Department of Emergency, University Hospital of Padova, Via Giustiniani, 2, 35128 Padova, Italy.
  • Previato L; Department of Medicine, University of Padova, Via VIII Febbraio, 2, 35122 Padova, Italy.
  • Toffolon A; Department of Medicine, University of Padova, Via VIII Febbraio, 2, 35122 Padova, Italy.
  • Sensi C; Department of Medicine, University of Padova, Via VIII Febbraio, 2, 35122 Padova, Italy.
  • Arcidiacono G; Department of Medicine, University of Padova, Via VIII Febbraio, 2, 35122 Padova, Italy.
  • Gorgi D; Department of Medicine, University of Padova, Via VIII Febbraio, 2, 35122 Padova, Italy.
  • Ippolito R; Department of Emergency, University Hospital of Padova, Via Giustiniani, 2, 35128 Padova, Italy.
  • Nessi E; Department of Emergency, University Hospital of Padova, Via Giustiniani, 2, 35128 Padova, Italy.
  • Pettenella P; Department of Emergency, University Hospital of Padova, Via Giustiniani, 2, 35128 Padova, Italy.
  • Cellini A; Department of Emergency, University Hospital of Padova, Via Giustiniani, 2, 35128 Padova, Italy.
  • Fossa C; Department of Emergency, University Hospital of Padova, Via Giustiniani, 2, 35128 Padova, Italy.
  • Vania E; Department of Emergency, University Hospital of Padova, Via Giustiniani, 2, 35128 Padova, Italy.
  • Gardin S; Department of Infectious Diseases, University Hospital of Padova, Via Giustiniani, 2, 35128 Padova, Italy.
  • Sukthi A; Department of Cardiac, Thoracic, Vascular Sciences and Public Health, University of Padova, Via Giustiniani, 2, 35128 Padova, Italy.
  • Luise D; Infectious and Tropical Diseases, San Bortolo Hospital, Viale Rodolfi, 37, 36100 Vicenza, Italy.
  • Giordani MT; Infectious and Tropical Diseases, San Bortolo Hospital, Viale Rodolfi, 37, 36100 Vicenza, Italy.
  • Zanatta M; Department of Emergency, Arzignano Hospital, Via del Parco, 1, 36071 Arzignano, Italy.
  • Savino S; Department of Medicine, University of Padova, Via VIII Febbraio, 2, 35122 Padova, Italy.
  • Cianci V; Department of Emergency, University Hospital of Padova, Via Giustiniani, 2, 35128 Padova, Italy.
  • Sattin A; Department of Infectious Diseases, University Hospital of Padova, Via Giustiniani, 2, 35128 Padova, Italy.
  • Maria A; Department of Infectious Diseases, University Hospital of Padova, Via Giustiniani, 2, 35128 Padova, Italy.
  • Vianello A; Department of Cardiac, Thoracic, Vascular Sciences and Public Health, University of Padova, Via Giustiniani, 2, 35128 Padova, Italy.
  • Pesavento R; Internal Medicine, Montebelluna Hospital, Via Palmiro Togliatti, 1, 31044 Montebelluna, Italy.
  • Giannini S; Department of Medicine, University of Padova, Via VIII Febbraio, 2, 35122 Padova, Italy.
  • Avogaro A; Department of Medicine, University of Padova, Via VIII Febbraio, 2, 35122 Padova, Italy.
  • Vettor R; Department of Medicine, University of Padova, Via VIII Febbraio, 2, 35122 Padova, Italy.
  • Fadini GP; Department of Medicine, University of Padova, Via VIII Febbraio, 2, 35122 Padova, Italy.
  • Saller A; Department of Medicine, University of Padova, Via VIII Febbraio, 2, 35122 Padova, Italy.
J Clin Med ; 10(6)2021 Mar 20.
Article in English | MEDLINE | ID: covidwho-1143527
ABSTRACT
BACKGROUND AND

AIM:

Lung ultrasound (LUS) is a convenient imaging modality in the setting of coronavirus disease-19 (COVID-19) because it is easily available, can be performed bedside and repeated over time. We herein examined LUS patterns in relation to disease severity and disease stage among patients with COVID-19 pneumonia.

METHODS:

We performed a retrospective case series analysis of patients with confirmed SARS-CoV-2 infection who were admitted to the hospital because of pneumonia. We recorded history, clinical parameters and medications. LUS was performed and scored in a standardized fashion by experienced operators, with evaluation of up to 12 lung fields, reporting especially on B-lines and consolidations.

RESULTS:

We included 96 patients, 58.3% men, with a mean age of 65.9 years. Patients with a high-risk quick COVID-19 severity index (qCSI) were older and had worse outcomes, especially for the need for high-flow oxygen. B-lines and consolidations were located mainly in the lower posterior lung fields. LUS patterns for B-lines and consolidations were significantly worse in all lung fields among patients with high versus low qCSI. B-lines and consolidations were worse in the intermediate disease stage, from day 7 to 13 after onset of symptoms. While consolidations correlated more with inflammatory biomarkers, B-lines correlated more with end-organ damage, including extrapulmonary involvement.

CONCLUSIONS:

LUS patterns provide a comprehensive evaluation of patients with COVID-19 pneumonia that correlated with severity and dynamically reflect disease stage. LUS patterns may reflect different pathophysiological processes related to inflammation or tissue damage; consolidations may represent a more specific sign of localized disease, whereas B-lines seem to be also dependent upon generalized illness due to SARS-CoV-2 infection.
Keywords

Full text: Available Collection: International databases Database: MEDLINE Type of study: Experimental Studies / Observational study / Prognostic study Language: English Year: 2021 Document Type: Article Affiliation country: Jcm10061288

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Experimental Studies / Observational study / Prognostic study Language: English Year: 2021 Document Type: Article Affiliation country: Jcm10061288