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Structure-Function Analyses of New SARS-CoV-2 Variants B.1.1.7, B.1.351 and B.1.1.28.1: Clinical, Diagnostic, Therapeutic and Public Health Implications.
Singh, Jasdeep; Samal, Jasmine; Kumar, Vipul; Sharma, Jyoti; Agrawal, Usha; Ehtesham, Nasreen Z; Sundar, Durai; Rahman, Syed Asad; Hira, Subhash; Hasnain, Seyed E.
  • Singh J; JH-Institute of Molecular Medicine, Jamia Hamdard, New Delhi 110062, India.
  • Samal J; ICMR National Institute of Pathology, Safdarjung Hospital Campus, New Delhi 110029, India.
  • Kumar V; Department of Biochemical Engineering and Biotechnology, Indian Institute of Technology, New Delhi 110016, India.
  • Sharma J; ICMR National Institute of Pathology, Safdarjung Hospital Campus, New Delhi 110029, India.
  • Agrawal U; ICMR National Institute of Pathology, Safdarjung Hospital Campus, New Delhi 110029, India.
  • Ehtesham NZ; ICMR National Institute of Pathology, Safdarjung Hospital Campus, New Delhi 110029, India.
  • Sundar D; Department of Biochemical Engineering and Biotechnology, Indian Institute of Technology, New Delhi 110016, India.
  • Rahman SA; BioInception Pvt. Ltd., Swift House Ground Floor, 18 Hoffmanns Way, Chelmsford, Essex CM1 1GU, UK.
  • Hira S; Department of Global Health, University of Washington-Seattle, Seattle, WA 98195, USA.
  • Hasnain SE; Department of Biochemical Engineering and Biotechnology, Indian Institute of Technology, New Delhi 110016, India.
Viruses ; 13(3)2021 03 09.
Article in English | MEDLINE | ID: covidwho-1143613
ABSTRACT
SARS-CoV-2 (Severe Acute Respiratory Syndrome-Coronavirus 2) has accumulated multiple mutations during its global circulation. Recently, three SARS-CoV-2 lineages, B.1.1.7 (501Y.V1), B.1.351 (501Y.V2) and B.1.1.28.1 (P.1), have emerged in the United Kingdom, South Africa and Brazil, respectively. Here, we have presented global viewpoint on implications of emerging SARS-CoV-2 variants based on structural-function impact of crucial mutations occurring in its spike (S), ORF8 and nucleocapsid (N) proteins. While the N501Y mutation was observed in all three lineages, the 501Y.V1 and P.1 accumulated a different set of mutations in the S protein. The missense mutational effects were predicted through a COVID-19 dedicated resource followed by atomistic molecular dynamics simulations. Current findings indicate that some mutations in the S protein might lead to higher affinity with host receptors and resistance against antibodies, but not all are due to different antibody binding (epitope) regions. Mutations may, however, result in diagnostic tests failures and possible interference with binding of newly identified anti-viral candidates against SARS-CoV-2, likely necessitating roll out of recurring "flu-like shots" annually for tackling COVID-19. The functional relevance of these mutations has been described in terms of modulation of host tropism, antibody resistance, diagnostic sensitivity and therapeutic candidates. Besides global economic losses, post-vaccine reinfections with emerging variants can have significant clinical, therapeutic and public health impacts.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: SARS-CoV-2 / COVID-19 Type of study: Diagnostic study / Prognostic study Topics: Vaccines / Variants Limits: Humans Language: English Year: 2021 Document Type: Article Affiliation country: V13030439

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Full text: Available Collection: International databases Database: MEDLINE Main subject: SARS-CoV-2 / COVID-19 Type of study: Diagnostic study / Prognostic study Topics: Vaccines / Variants Limits: Humans Language: English Year: 2021 Document Type: Article Affiliation country: V13030439