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A Descriptive-Multivariate Analysis of Community Knowledge, Confidence, and Trust in COVID-19 Clinical Trials among Healthcare Workers in Uganda.
Kasozi, Keneth Iceland; Laudisoit, Anne; Osuwat, Lawrence Obado; Batiha, Gaber El-Saber; Al Omairi, Naif E; Aigbogun, Eric; Ninsiima, Herbert Izo; Usman, Ibe Michael; DeTora, Lisa M; MacLeod, Ewan Thomas; Nalugo, Halima; Crawley, Francis P; Bierer, Barbara E; Mwandah, Daniel Chans; Kato, Charles Drago; Kiyimba, Kenedy; Ayikobua, Emmanuel Tiyo; Lillian, Linda; Matama, Kevin; Nelly Mak, Shui Ching; Onanyang, David; Pius, Theophilus; Nalumenya, David Paul; Ssebuufu, Robinson; Rugambwa, Nina Olivia; Musoke, Grace Henry; Bardosh, Kevin; Ochieng, Juma John; Ssempijja, Fred; Kyamanywa, Patrick; Tumwine, Gabriel; Alzahrani, Khalid J; Welburn, Susan Christina.
  • Kasozi KI; Infection Medicine, Deanery of Biomedical Sciences, College of Medicine and Veterinary Medicine, The University of Edinburgh, 1 George Square, Edinburgh EH8 9JZ, UK.
  • Laudisoit A; School of Medicine, Kabale University, P.O. Box 317 Kabale, Uganda.
  • Osuwat LO; EcoHealth Alliance, 520 Eighth Ave, Suite 1201, New York, NY 10018, USA.
  • Batiha GE; School of Health Sciences, Soroti University, P.O. Box 211 Soroti, Uganda.
  • Al Omairi NE; Department of Pharmacology and Therapeutics, Faculty of Veterinary Medicine, Damanhour University, Damanhour 22511, AlBeheira, Egypt.
  • Aigbogun E; Department of Internal Medicine, College of Medicine, Taif University, P.O. Box 11099, Taif 21944, Saudi Arabia.
  • Ninsiima HI; Kampala International University Western Campus, P.O. Box 71 Bushenyi, Uganda.
  • Usman IM; School of Medicine, Kabale University, P.O. Box 317 Kabale, Uganda.
  • DeTora LM; Kampala International University Western Campus, P.O. Box 71 Bushenyi, Uganda.
  • MacLeod ET; Department of Writing Studies and Rhetoric, Hofstra University, Hempstead, NY 11549, USA.
  • Nalugo H; Infection Medicine, Deanery of Biomedical Sciences, College of Medicine and Veterinary Medicine, The University of Edinburgh, 1 George Square, Edinburgh EH8 9JZ, UK.
  • Crawley FP; Faculty of Medicine, Mbarara University of Science and Technology, P.O. Box 1410 Mbarara, Uganda.
  • Bierer BE; Good Clinical Practice Alliance-Europe and Strategic Initiative for Developing Capacity in Ethical Review, BE-1050 Brussels, Belgium.
  • Mwandah DC; Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
  • Kato CD; Faculty of Science, Muni University, P.O. Box 725 Arua, Uganda.
  • Kiyimba K; College of Veterinary Medicine Animal Resources and Biosecurity, Makerere University, P.O. Box 7062 Kampala, Uganda.
  • Ayikobua ET; Department of Pharmacology and Therapeutics, Faculty of Health sciences, Busitema University, P.O. Box 206 Mbale, Uganda.
  • Lillian L; School of Health Sciences, Soroti University, P.O. Box 211 Soroti, Uganda.
  • Matama K; Uganda National Health Laboratory Services, Ministry of Health, P.O. Box 7272 Kampala, Uganda.
  • Nelly Mak SC; Kampala International University Western Campus, P.O. Box 71 Bushenyi, Uganda.
  • Onanyang D; Infection Medicine, Deanery of Biomedical Sciences, College of Medicine and Veterinary Medicine, The University of Edinburgh, 1 George Square, Edinburgh EH8 9JZ, UK.
  • Pius T; Department of biology, Faculty of Science, Gulu University, P.O. Box 166 Gulu, Uganda.
  • Nalumenya DP; Kampala International University Western Campus, P.O. Box 71 Bushenyi, Uganda.
  • Ssebuufu R; College of Veterinary Medicine Animal Resources and Biosecurity, Makerere University, P.O. Box 7062 Kampala, Uganda.
  • Rugambwa NO; Kampala International University Western Campus, P.O. Box 71 Bushenyi, Uganda.
  • Musoke GH; Department of Library and Information Science, Faculty of Computing, Library and Information Science, P.O. Box 317 Kabale, Uganda.
  • Bardosh K; Faculty of Science and Technology, Cavendish University, P.O. Box 33145 Kampala, Uganda.
  • Ochieng JJ; Center for One Health Research, School of Public Health, University of Washington, Seattle, WA 98195, USA.
  • Ssempijja F; Kampala International University Western Campus, P.O. Box 71 Bushenyi, Uganda.
  • Kyamanywa P; Kampala International University Western Campus, P.O. Box 71 Bushenyi, Uganda.
  • Tumwine G; Kampala International University Western Campus, P.O. Box 71 Bushenyi, Uganda.
  • Alzahrani KJ; College of Veterinary Medicine Animal Resources and Biosecurity, Makerere University, P.O. Box 7062 Kampala, Uganda.
  • Welburn SC; Department of Clinical Laboratories Sciences, College of Applied Medical Sciences, Taif University, P.O. Box 11099, Taif 21944, Saudi Arabia.
Vaccines (Basel) ; 9(3)2021 Mar 12.
Article in English | MEDLINE | ID: covidwho-1143623
ABSTRACT
Background-misinformation and mistrust often undermines community vaccine uptake, yet information in rural communities, especially of developing countries, is scarce. This study aimed to identify major challenges associated with coronavirus disease 2019 (COVID-19) vaccine clinical trials among healthcare workers and staff in Uganda. Methods-a rapid exploratory survey was conducted over 5 weeks among 260 respondents (66% male) from healthcare centers across the country using an online questionnaire. Twenty-seven questions assessed knowledge, confidence, and trust scores on COVID-19 vaccine clinical trials from participants in 46 districts in Uganda. Results-we found low levels of knowledge (i.e., confusing COVID-19 with Ebola) with males being more informed than females (OR = 1.5, 95% CI 0.7-3.0), and mistrust associated with policy decisions to promote herbal treatments in Uganda and the rushed international clinical trials, highlighting challenges for the upcoming Oxford-AstraZeneca vaccinations. Knowledge, confidence and trust scores were higher among the least educated (certificate vs. bachelor degree holders). We also found a high level of skepticism and possible community resistance to DNA recombinant vaccines, such as the Oxford-AstraZeneca vaccine. Preference for herbal treatments (38/260; 14.6%, 95% CI 10.7-19.3) currently being promoted by the Ugandan government raises major policy concerns. High fear and mistrust for COVID-19 vaccine clinical trials was more common among wealthier participants and more affluent regions of the country. Conclusion-our study found that knowledge, confidence, and trust in COVID-19 vaccines was low among healthcare workers in Uganda, especially those with higher wealth and educational status. There is a need to increase transparency and inclusive participation to address these issues before new trials of COVID-19 vaccines are initiated.
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Full text: Available Collection: International databases Database: MEDLINE Type of study: Observational study / Prognostic study Topics: Traditional medicine / Vaccines Language: English Year: 2021 Document Type: Article Affiliation country: Vaccines9030253

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Observational study / Prognostic study Topics: Traditional medicine / Vaccines Language: English Year: 2021 Document Type: Article Affiliation country: Vaccines9030253