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Impact of the COVID-19 pandemic on liver donation and transplantation: A review of the literature.
De Carlis, Riccardo; Vella, Ivan; Incarbone, Niccolò; Centonze, Leonardo; Buscemi, Vincenzo; Lauterio, Andrea; De Carlis, Luciano.
  • De Carlis R; Department of General Surgery and Transplantation, ASST Grande Ospedale Metropolitano Niguarda, Milan 20162, Italy. riccardo.decarlis@ospedaleniguarda.it.
  • Vella I; Department of General Surgery and Transplantation, ASST Grande Ospedale Metropolitano Niguarda, Milan 20162, Italy.
  • Incarbone N; Department of General Surgery and Transplantation, ASST Grande Ospedale Metropolitano Niguarda, Milan 20162, Italy.
  • Centonze L; Department of General Surgery and Transplantation, ASST Grande Ospedale Metropolitano Niguarda, Milan 20162, Italy.
  • Buscemi V; Department of General Surgery and Transplantation, ASST Grande Ospedale Metropolitano Niguarda, Milan 20162, Italy.
  • Lauterio A; Department of General Surgery and Transplantation, ASST Grande Ospedale Metropolitano Niguarda, Milan 20162, Italy.
  • De Carlis L; Department of General Surgery and Transplantation, ASST Grande Ospedale Metropolitano Niguarda, Milan 20162, Italy.
World J Gastroenterol ; 27(10): 928-938, 2021 Mar 14.
Article in English | MEDLINE | ID: covidwho-1143627
ABSTRACT
The coronavirus disease 2019 (COVID-19) pandemic has upended healthcare systems worldwide and led to an inevitable decrease in liver transplantation (LT) activity. During the first pandemic wave, administrators and clinicians were obliged to make the difficult decision of whether to suspend or continue a life-saving procedure based on the scarce available evidence regarding the risk of transmission and mortality in immunosuppressed patients. Those centers where the activity continued or was heavily restricted were obliged to screen donors and recipients, design COVID-safe clinical pathways, and promote telehealth to prevent nosocomial transmission. Despite the ever-growing literature on COVID-19, the amount of high-quality literature on LT remains limited. This review will provide an updated view of the impact of the pandemic on LT programs worldwide. Donor and recipient screening, strategies for waitlist prioritization, and posttransplant risk of infection and mortality are discussed. Moreover, a particular focus is given to the possibility of donor-to-recipient transmission and immunosuppression management in COVID-positive recipients.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Tissue and Organ Procurement / Liver Transplantation / COVID-19 Type of study: Diagnostic study / Experimental Studies / Observational study / Prognostic study Limits: Humans Language: English Journal: World J Gastroenterol Journal subject: Gastroenterology Year: 2021 Document Type: Article Affiliation country: Wjg.v27.i10.928

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Tissue and Organ Procurement / Liver Transplantation / COVID-19 Type of study: Diagnostic study / Experimental Studies / Observational study / Prognostic study Limits: Humans Language: English Journal: World J Gastroenterol Journal subject: Gastroenterology Year: 2021 Document Type: Article Affiliation country: Wjg.v27.i10.928