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SARS-CoV-2 infection and smoking: What is the association? A brief review.
Gupta, Ishita; Sohail, Muhammad Umar; Elzawawi, Khaled E; Amarah, Ahmed H; Vranic, Semir; Al-Asmakh, Maha; Al Moustafa, Ala-Eddin.
  • Gupta I; College of Medicine, QU Health, Qatar University, Doha, Qatar.
  • Sohail MU; Biomedical and Pharmaceutical Research Unit, QU Health, Qatar University, Doha, Qatar.
  • Elzawawi KE; Proteomics Core, Weill Cornell Medicine, Qatar Foundation - Education City, P. O. Box 24144, Doha, Qatar.
  • Amarah AH; College of Medicine, QU Health, Qatar University, Doha, Qatar.
  • Vranic S; College of Medicine, QU Health, Qatar University, Doha, Qatar.
  • Al-Asmakh M; College of Medicine, QU Health, Qatar University, Doha, Qatar.
  • Al Moustafa AE; Biomedical and Pharmaceutical Research Unit, QU Health, Qatar University, Doha, Qatar.
Comput Struct Biotechnol J ; 19: 1654-1660, 2021.
Article in English | MEDLINE | ID: covidwho-2261625
ABSTRACT
Susceptibility to severe illness from COVID-19 is anticipated to be associated with cigarette smoking as it aggravates the risk of cardiovascular and respiratory illness, including infections. This is particularly important with the advent of a new strain of coronaviruses, the severe acute respiratory syndrome coronavirus (SARS-CoV-2) that has led to the present pandemic, coronavirus disease 2019 (COVID-19). Although, the effects of smoking on COVID-19 are less described and controversial, we presume a link between smoking and COVID-19. Smoking has been shown to enhance the expression of the angiotensin-converting enzyme-2 (ACE-2) and transmembrane serine protease 2 (TMPRSS2) key entry genes utilized by SARS-CoV-2 to infect cells and induce a 'cytokine storm', which further increases the severity of COVID-19 clinical course. Nevertheless, the impact of smoking on ACE-2 and TMPRSS2 receptors expression remains paradoxical. Thus, further research is necessary to unravel the association between smoking and COVID-19 and to pursue the development of potential novel therapies that are able to constrain the morbidity and mortality provoked by this infectious disease. Herein we present a brief overview of the current knowledge on the correlation between smoking and the expression of SARS-CoV-2 key entry genes, clinical manifestations, and disease progression.
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Full text: Available Collection: International databases Database: MEDLINE Type of study: Prognostic study Language: English Journal: Comput Struct Biotechnol J Year: 2021 Document Type: Article Affiliation country: J.csbj.2021.03.023

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Prognostic study Language: English Journal: Comput Struct Biotechnol J Year: 2021 Document Type: Article Affiliation country: J.csbj.2021.03.023