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Fibrinolysis Shutdown in COVID-19: Clinical Manifestations, Molecular Mechanisms, and Therapeutic Implications.
Meizoso, Jonathan P; Moore, Hunter B; Moore, Ernest E.
  • Meizoso JP; Ernest E Moore Shock Trauma Center, Denver Health Medical Center, University of Colorado, Denver, CO. Electronic address: jonathan.meizoso@cuanschutz.edu.
  • Moore HB; Division of Transplant Surgery, University of Colorado, Denver, CO.
  • Moore EE; Ernest E Moore Shock Trauma Center, Denver Health Medical Center, University of Colorado, Denver, CO.
J Am Coll Surg ; 232(6): 995-1003, 2021 06.
Article in English | MEDLINE | ID: covidwho-1144761
ABSTRACT
The COVID-19 pandemic has introduced a global public health threat unparalleled in our history. The most severe cases are marked by ARDS attributed to microvascular thrombosis. Hypercoagulability, resulting in a profoundly prothrombotic state, is a distinct feature of COVID-19 and is accentuated by a high incidence of fibrinolysis shutdown. The aims of this review were to describe the manifestations of fibrinolysis shutdown in COVID-19 and its associated outcomes, review the molecular mechanisms of dysregulated fibrinolysis associated with COVID-19, and discuss potential implications and therapeutic targets for patients with severe COVID-19.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Thrombophilia / Fibrinolysis / COVID-19 Type of study: Observational study / Prognostic study Topics: Long Covid Limits: Humans Language: English Journal: J Am Coll Surg Journal subject: Gynecology / Obstetrics Year: 2021 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Thrombophilia / Fibrinolysis / COVID-19 Type of study: Observational study / Prognostic study Topics: Long Covid Limits: Humans Language: English Journal: J Am Coll Surg Journal subject: Gynecology / Obstetrics Year: 2021 Document Type: Article