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Paediatric multisystem inflammatory syndrome temporally associated with SARS-CoV-2 (PIMS-TS): Prospective, national surveillance, United Kingdom and Ireland, 2020.
Flood, Jessica; Shingleton, Joseph; Bennett, Emma; Walker, Brodie; Amin-Chowdhury, Zahin; Oligbu, Godwin; Avis, Jacob; Lynn, Richard M; Davis, Peter; Bharucha, Tara; Pain, Clare E; Jyothish, Deepthi; Whittaker, Elizabeth; Dwarakanathan, Buvana; Wood, Rachael; Williams, Christopher; Swann, Olivia; Semple, Malcolm G; Ramsay, Mary E; Jones, Christine E; Ramanan, Athimalaipet V; Gent, Nick; Ladhani, Shamez N.
  • Flood J; Immunisation and Countermeasures Division, Public Health England, London, UK.
  • Shingleton J; Emergency Response Department, Public Health England, Porton Down, UK.
  • Bennett E; Public Health England's Joint Modelling Cell, Public Health England, Porton Down, UK.
  • Walker B; Emergency Response Department, Public Health England, Porton Down, UK.
  • Amin-Chowdhury Z; Public Health England's Joint Modelling Cell, Public Health England, Porton Down, UK.
  • Oligbu G; Emergency Response Department, Public Health England, Porton Down, UK.
  • Avis J; Public Health England's Joint Modelling Cell, Public Health England, Porton Down, UK.
  • Lynn RM; Immunisation and Countermeasures Division, Public Health England, London, UK.
  • Davis P; Immunisation and Countermeasures Division, Public Health England, London, UK.
  • Bharucha T; BPSU, Royal College of Paediatrics, London, UK.
  • Pain CE; BPSU, Royal College of Paediatrics, London, UK.
  • Jyothish D; Institute of Child Health, University College London Research Department of Epidemiology and Public Health, London, UK.
  • Whittaker E; Paediatric Intensive Care Unit, Bristol Royal Hospital for Children, UK.
  • Dwarakanathan B; Department of congenital cardiology, University Hospital Southampton NHS Foundation Trust, Southampton, UK.
  • Wood R; BMBS, Alder Hey Children's NHS Foundation Trust, Liverpool, UK.
  • Williams C; Birmingham Children's Hospital, Birmingham Women's and Children's NHS Foundation Trust, Birmingham, UK.
  • Swann O; Paediatrics, Imperial College London Faculty of Medicine, London, UK.
  • Semple MG; Paediatric Intensive Care Unit, St George's Hospital, London, UK.
  • Ramsay ME; Public Health Scotland, UK.
  • Jones CE; Centre for Clinical Brain Sciences, University of Edinburgh, UK.
  • Ramanan AV; Public Health Wales, Cardiff, UK.
  • Gent N; Department of Child Life and Health, University of Edinburgh, Edinburgh, UK.
  • Ladhani SN; Royal Hospital for Sick Children, Paediatric Infectious Diseases, Edinburgh, UK.
Lancet Reg Health Eur ; 3: 100075, 2021 Apr.
Article in English | MEDLINE | ID: covidwho-1144857
Semantic information from SemMedBD (by NLM)
1. Antibodies PART_OF 2019 novel coronavirus
Subject
Antibodies
Predicate
PART_OF
Object
2019 novel coronavirus
2. Toxic Shock Syndrome PROCESS_OF Child
Subject
Toxic Shock Syndrome
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PROCESS_OF
Object
Child
3. Cardiac Arrest PROCESS_OF Child
Subject
Cardiac Arrest
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PROCESS_OF
Object
Child
4. Complication PROCESS_OF Child
Subject
Complication
Predicate
PROCESS_OF
Object
Child
5. Complication PROCESS_OF Adolescent (age group)
Subject
Complication
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PROCESS_OF
Object
Adolescent (age group)
6. pediatric multisystem inflammatory diseas PROCESS_OF C0008059
Subject
pediatric multisystem inflammatory diseas
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PROCESS_OF
Object
C0008059
7. Antibodies PART_OF 2019 novel coronavirus
Subject
Antibodies
Predicate
PART_OF
Object
2019 novel coronavirus
8. Toxic Shock Syndrome PROCESS_OF Child
Subject
Toxic Shock Syndrome
Predicate
PROCESS_OF
Object
Child
9. Cardiac Arrest PROCESS_OF Child
Subject
Cardiac Arrest
Predicate
PROCESS_OF
Object
Child
10. Complication PROCESS_OF Child
Subject
Complication
Predicate
PROCESS_OF
Object
Child
11. Complication PROCESS_OF Adolescent (age group)
Subject
Complication
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PROCESS_OF
Object
Adolescent (age group)
12. pediatric multisystem inflammatory disease, COVID-19 related PROCESS_OF Child
Subject
pediatric multisystem inflammatory disease, COVID-19 related
Predicate
PROCESS_OF
Object
Child
ABSTRACT

BACKGROUND:

Paediatric Multisystem Inflammatory Syndrome temporally associated with SARS-CoV-2 (PIMS-TS), first identified in April 2020, shares features of both Kawasaki disease (KD) and toxic shock syndrome (TSS). The surveillance describes the epidemiology and clinical characteristics of PIMS-TS in the United Kingdom and Ireland.

METHODS:

Public Health England initiated prospective national surveillance of PIMS-TS through the British Paediatric Surveillance Unit. Paediatricians were contacted monthly to report PIMS-TS, KD and TSS cases electronically and complete a detailed clinical questionnaire. Cases with symptom onset between 01 March and 15 June 2020 were included.

FINDINGS:

There were 216 cases with features of PIMS-TS alone, 13 with features of both PIMS-TS and KD, 28 with features of PIMS-TS and TSS and 11 with features of PIMS-TS, KD and TSS, with differences in age, ethnicity, clinical presentation and disease severity between the phenotypic groups. There was a strong geographical and temporal association between SARS-CoV-2 infection rates and PIMS-TS cases. Of those tested, 14.8% (39/264) children had a positive SARS-CoV-2 RT-PCR, and 63.6% (75/118) were positive for SARS-CoV-2 antibodies. In total 44·0% (118/268) required intensive care, which was more common in cases with a TSS phenotype. Three of five children with cardiac arrest had TSS phenotype. Three children (1·1%) died.

INTERPRETATION:

The strong association between SARS-CoV-2 infection and PIMS-TS emphasises the importance of maintaining low community infection rates to reduce the risk of this rare but severe complication in children and adolescents. Close follow-up will be important to monitor long-term complications in children with PIMS-TS.

FUNDING:

PHE.

Full text: Available Collection: International databases Database: MEDLINE Type of study: Observational study / Prognostic study / Randomized controlled trials / Risk factors / Screening study Topics: Long Covid Language: English Journal: Lancet Reg Health Eur Year: 2021 Document Type: Article Affiliation country: J.lanepe.2021.100075

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Observational study / Prognostic study / Randomized controlled trials / Risk factors / Screening study Topics: Long Covid Language: English Journal: Lancet Reg Health Eur Year: 2021 Document Type: Article Affiliation country: J.lanepe.2021.100075