Elevated fibrinogen and fibrin degradation product are associated with poor outcome in COVID-19 patients: A meta-analysis.
Clin Hemorheol Microcirc
; 77(2): 221-231, 2021.
Article
in English
| MEDLINE | ID: covidwho-1145547
ABSTRACT
INTRODUCTION:
COVID-19 is a systemic infection with a significant impact on coagulation which manifests in thromboembolism. There is an unknown relationship of which coagulation profile parameter at presentation has an association with poor outcome in COVID-19.OBJECTIVE:
This meta-analysis aimed to determine the relationship between fibrinogen and FDP with poor outcome in COVID-19 patients.METHODS:
A systematic search of all observational studies or trials involving adult patients with COVID-19 that had any data fibrinogen or FDP on admission was carried out using the PubMed, Science Direct, Scopus, ProQuest, and MedRxiv databases. We assessed the methodological quality assessment using the NIH Quality Assessment Tool. We performed random-effects inverse-variance weighting analysis using mean difference (MD).RESULTS:
A total of 17 studies (1,654 patients) were included in this meta-analysis. It revealed a higher mean of fibrinogen levels on admission in patients with severe case compared to those with non-severe case (MDâ=â0.69, [95% CI 0.44 to 0.94], pâ<â0.05; I2â=â72%, pâ<â0.05). Non-survivor group had a pooled higher mean difference of fibrinogen values on admission (MDâ=â0.48 [95% CI 0.13 to 0.83], pâ<â0.05; I2â=â38%, pâ=â0.18). Higher FDP on admission was found in poor outcome (composite of severity, critically ill, and mortality) compared to good outcome (4 studies, MDâ=â4.84 [95% CI 0.75 to 8.93], pâ<â0.05; I2â=â86%, pâ<â0.05).CONCLUSION:
Elevated fibrinogen and FDP level on admission were associated with an increase risk of poor outcome in COVID-19 patients.Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Fibrin Fibrinogen Degradation Products
/
Fibrinogen
/
COVID-19
Type of study:
Observational study
/
Prognostic study
/
Randomized controlled trials
/
Reviews
/
Systematic review/Meta Analysis
Limits:
Humans
Language:
English
Journal:
Clin Hemorheol Microcirc
Journal subject:
Vascular Diseases
/
Hematology
Year:
2021
Document Type:
Article
Affiliation country:
CH-200978
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