Clinical Features and Outcomes of Patients with Dementia Compared to an Aging Cohort Hospitalized During the Initial New York City COVID-19 Wave.
J Alzheimers Dis
; 81(2): 679-690, 2021.
Article
in English
| MEDLINE | ID: covidwho-1145549
ABSTRACT
BACKGROUND:
Patients with dementia are vulnerable during the coronavirus disease 2019 (COVID-19) pandemic, yet few studies describe their hospital course and outcomes.OBJECTIVE:
To describe and compare the hospital course for COVID-19 patients with dementia to an aging cohort without dementia in a large New York City academic medical center.METHODS:
This was a single-center retrospective cohort study describing all consecutive patients age 65 or older with confirmed COVID-19 who presented to the emergency department or were hospitalized at New York-Presbyterian/Columbia University Irving Medical Center between March 6 and April 7, 2020.RESULTS:
A total of 531 patients were evaluated, including 116 (21.8%) with previously diagnosed dementia, and 415 without dementia. Patients with dementia had higher mortality (50.0%versus 35.4%, pâ=â0.006); despite similar comorbidities and complications, multivariate analysis indicated the association was dependent on age, sex, comorbidities, and code status. Patients with dementia more often presented with delirium (36.2%versus 11.6%, pâ<â0.001) but less often presented with multiple other COVID-19 symptoms, and these findings remained after adjusting for age and sex.CONCLUSION:
Hospitalized COVID-19 patients with dementia had higher mortality, but dementia was not an independent risk factor for death. These patients were approximately 3 times more likely to present with delirium but less often manifested or communicated other common COVID-19 symptoms. For this high-risk population in a worsening pandemic, understanding the unique manifestations and course in dementia and aging populations may help guide earlier diagnosis and optimize medical management.Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Delirium
/
Dementia
/
COVID-19
Type of study:
Cohort study
/
Experimental Studies
/
Observational study
/
Prognostic study
Limits:
Aged
/
Female
/
Humans
/
Male
Country/Region as subject:
North America
Language:
English
Journal:
J Alzheimers Dis
Journal subject:
Geriatrics
/
Neurology
Year:
2021
Document Type:
Article
Affiliation country:
JAD-210050
Similar
MEDLINE
...
LILACS
LIS