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Hiding in Plain Sight: an Approach to Treating Patients with Severe COVID-19 Infection.
Fedson, David S; Opal, Steven M; Rordam, Ole Martin.
  • Fedson DS; 57, chemin du Lavoir, Sergy Haut, France davidsfedson@gmail.com.
  • Opal SM; Department of Medicine, Warren Alpert Medical School of Brown University, Providence, Rhode Island, USA.
  • Rordam OM; Fyordgata 59, Trondheim, Norway.
mBio ; 11(2)2020 03 20.
Article in English | MEDLINE | ID: covidwho-11461
ABSTRACT
Patients with COVID-19 infection are at risk of acute respiratory disease syndrome (ARDS) and death. The tissue receptor for COVID-19 is ACE2, and higher levels of ACE2 can protect against ARDS. Angiotensin receptor blockers and statins upregulate ACE2. Clinical trials are needed to determine whether this drug combination might be used to treat patients with severe COVID-19 infection.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Receptors, Virus / Coronavirus Infections / Receptor, Angiotensin, Type 2 / Betacoronavirus Type of study: Prognostic study Limits: Humans Language: English Year: 2020 Document Type: Article Affiliation country: MBio.00398-20

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Receptors, Virus / Coronavirus Infections / Receptor, Angiotensin, Type 2 / Betacoronavirus Type of study: Prognostic study Limits: Humans Language: English Year: 2020 Document Type: Article Affiliation country: MBio.00398-20