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Evaluation of epidemiology, clinical features, prognosis, diagnosis and treatment outcomes of patients with COVID-19 in West Azerbaijan Province.
Gharebaghi, Naser; Farshid, Saman; Boroofeh, Behdad; Nejadrahim, Rahim; Mousavi, Jalil; Dindarian, Sina; Mohammadi, Sedra.
  • Gharebaghi N; Department of Infectious Diseases and Dermatology, Urmia University of Medical Sciences, Urmia, Iran.
  • Farshid S; Department of Urology and Nephrology, Urmia University of Medical Sciences, Urmia, Iran.
  • Boroofeh B; Department of Pulmonology, Urmia University of Medical Sciences, Urmia, Iran.
  • Nejadrahim R; Department of Infectious Diseases and Dermatology, Urmia University of Medical Sciences, Urmia, Iran.
  • Mousavi J; Department of Infectious Diseases and Dermatology, Urmia University of Medical Sciences, Urmia, Iran.
  • Dindarian S; Student Research Committee, Urmia University of Medical Sciences, Urmia, Iran.
  • Mohammadi S; Student Research Committee, Urmia University of Medical Sciences, Urmia, Iran.
Int J Clin Pract ; 75(6): e14108, 2021 Jun.
Article in English | MEDLINE | ID: covidwho-1146529
ABSTRACT

BACKGROUND:

COVID-19 is considered a widespread concern in global public health. Diagnoses of COVID-19 in some cases are necessary because of severe prognosis. In this study, epidemiologies, clinical and demographic characteristics of patients with COVID-19 were studied in Taleghani Hospital, Urmia, Iran.

METHODS:

This descriptive-analytical cross-sectional study was carried out on 215 patients with COVID-19 during March and April 2020. Approved COVID-19 case was considered as a person with a positive respiratory sample performed by at least one of two RT-PCR methods or genetic sequencing. ANOVA repeated measure, independent t-test and logistic regression were done. A P < .05 was considered significant.

RESULTS:

The mean age of patients was 50.93 ± 17.92 years. Regarding gender, there were 91 females (42.3%) and 124 males (57.7%). The mean hospital stay, the temperature at admission, and onset of symptoms were 4.91 ± 3.68 days, 37.40 ± 0.96°C and 5.88 ± 4.80 days, respectively. Close contact with suspected people was found in 10.2% of patients. Additionally, 44 patients (20.5%) were smokers. Shortness of breath and cough were found in 62.8% and 49.3% of patients. Diabetes mellitus and hypertension were the most common comorbidities of patients. Regarding lung involvement, 33 patients (33%) were normal, most of the patients (n = 71) had 5%-25% involvement in their lung and a minority of patients (n = 13) had a severe condition of 50%-75% lung involvement. The association between smoking and mortality was tested using chi-square showing no significant difference (X22.959, P = .085). There was no significant difference between AST, ALT, ALP, total, direct Bilirubin, lung involvement and suffering from fever (P > .05). High Spo2 can increase the chance of recovery by 24% with each unit reduction. Kidney involvement increases the chance of death by about 80% (95% CI 0.104-0.013). The odds ratio of spo2 for recovery of COVID-19 was 1.24 (95% CI 1.014-1.528; P = .037). Kaletra with odds ratio of 31.960 had the most highest effect on recovery following COVID-19 (P = .043).

CONCLUSION:

COVID-19 involves different organs of the body with different severity. In the meantime, smoking was not a risk factor for the virus or associated with severe manifestations of the disease. Patients with high creatinine and CPK, pulmonary involvement above 25%, and hypoxemia had a higher mortality rate. Increase of Spo2 by 1% can improve the patients by 24%. The results indicated that Kaletra had the most highest effect on improvement following COVID-19.
Subject(s)

Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Type of study: Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Limits: Adult / Aged / Female / Humans / Male / Middle aged Country/Region as subject: Asia / Europa Language: English Journal: Int J Clin Pract Journal subject: Medicine Year: 2021 Document Type: Article Affiliation country: Ijcp.14108

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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Type of study: Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Limits: Adult / Aged / Female / Humans / Male / Middle aged Country/Region as subject: Asia / Europa Language: English Journal: Int J Clin Pract Journal subject: Medicine Year: 2021 Document Type: Article Affiliation country: Ijcp.14108