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Immune reconstitution and severity of COVID-19 among hematopoietic cell transplant recipients.
Malek, Alexandre E; Adachi, Javier A; Mulanovich, Victor E; Sassine, Joseph; Raad, Issam I; McConn, Kelly; Seiler, Garret T; Dhal, Udit; Khawaja, Fareed; Chemaly, Roy F.
  • Malek AE; Department of Infectious Diseases, Infection Control and Employee Health, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
  • Adachi JA; Department of Infectious Diseases, Infection Control and Employee Health, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
  • Mulanovich VE; Department of Infectious Diseases, Infection Control and Employee Health, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
  • Sassine J; Department of Infectious Diseases, Infection Control and Employee Health, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
  • Raad II; Department of Infectious Diseases, Infection Control and Employee Health, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
  • McConn K; Department of Infectious Diseases, Infection Control and Employee Health, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
  • Seiler GT; Department of Infectious Diseases, Infection Control and Employee Health, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
  • Dhal U; Department of Infectious Diseases, Infection Control and Employee Health, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
  • Khawaja F; Department of Infectious Diseases, Infection Control and Employee Health, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
  • Chemaly RF; Department of Infectious Diseases, Infection Control and Employee Health, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Transpl Infect Dis ; 23(4): e13606, 2021 Aug.
Article in English | MEDLINE | ID: covidwho-1146666
ABSTRACT
Severe acute respiratory syndrome coronavirus 2 can lead to life-threatening coronavirus disease 2019 (COVID-19) infections in patients with hematologic malignancies, particularly among hematopoietic cell transplant (HCT) recipients. We describe two patients with COVID-19 during the pre-engraftment period after HCT and review previous reports of COVID-19 in HCT recipients. Because of significant mortality from COVID-19, primarily after allogeneic HCT, early, preemptive, and optimal directed therapy may improve outcomes and reduce the mortality rate but still needs to be established in clinical trials.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Hematopoietic Stem Cell Transplantation / Immune Reconstitution / COVID-19 Type of study: Case report / Prognostic study Limits: Humans Language: English Journal: Transpl Infect Dis Journal subject: Transplantation Year: 2021 Document Type: Article Affiliation country: Tid.13606

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Hematopoietic Stem Cell Transplantation / Immune Reconstitution / COVID-19 Type of study: Case report / Prognostic study Limits: Humans Language: English Journal: Transpl Infect Dis Journal subject: Transplantation Year: 2021 Document Type: Article Affiliation country: Tid.13606