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Obesity, Ethnicity, and Risk of Critical Care, Mechanical Ventilation, and Mortality in Patients Admitted to Hospital with COVID-19: Analysis of the ISARIC CCP-UK Cohort.
Yates, Thomas; Zaccardi, Francesco; Islam, Nazrul; Razieh, Cameron; Gillies, Clare L; Lawson, Claire A; Chudasama, Yogini; Rowlands, Alex; Davies, Melanie J; Docherty, Annemarie B; Openshaw, Peter J M; Baillie, J Kenneth; Semple, Malcolm G; Khunti, Kamlesh.
  • Yates T; Diabetes Research Centre, University of Leicester, Leicester General Hospital, Leicester, UK.
  • Zaccardi F; National Institute for Health Research (NIHR) Leicester Biomedical Research Centre (BRC), University Hospitals of Leicester NHS Trust and University of Leicester, Leicester, UK.
  • Islam N; Diabetes Research Centre, University of Leicester, Leicester General Hospital, Leicester, UK.
  • Razieh C; Leicester Real World Evidence Unit, Diabetes Research Centre, University of Leicester, Leicester, UK.
  • Gillies CL; Clinical Trial Service Unit and Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health, University of Oxford, Oxford, UK.
  • Lawson CA; Medical Research Council Epidemiology Unit, University of Cambridge, Cambridge, UK.
  • Chudasama Y; Diabetes Research Centre, University of Leicester, Leicester General Hospital, Leicester, UK.
  • Rowlands A; National Institute for Health Research (NIHR) Leicester Biomedical Research Centre (BRC), University Hospitals of Leicester NHS Trust and University of Leicester, Leicester, UK.
  • Davies MJ; Diabetes Research Centre, University of Leicester, Leicester General Hospital, Leicester, UK.
  • Docherty AB; Leicester Real World Evidence Unit, Diabetes Research Centre, University of Leicester, Leicester, UK.
  • Openshaw PJM; Diabetes Research Centre, University of Leicester, Leicester General Hospital, Leicester, UK.
  • Baillie JK; Leicester Real World Evidence Unit, Diabetes Research Centre, University of Leicester, Leicester, UK.
  • Semple MG; Diabetes Research Centre, University of Leicester, Leicester General Hospital, Leicester, UK.
  • Khunti K; Diabetes Research Centre, University of Leicester, Leicester General Hospital, Leicester, UK.
Obesity (Silver Spring) ; 29(7): 1223-1230, 2021 07.
Article in English | MEDLINE | ID: covidwho-1146942
Semantic information from SemMedBD (by NLM)
1. Obesity PROCESS_OF Patients
Subject
Obesity
Predicate
PROCESS_OF
Object
Patients
2. Obesity PROCESS_OF Ethnic group
Subject
Obesity
Predicate
PROCESS_OF
Object
Ethnic group
3. Obesity PROCESS_OF Patients
Subject
Obesity
Predicate
PROCESS_OF
Object
Patients
4. Obesity PROCESS_OF Ethnic group
Subject
Obesity
Predicate
PROCESS_OF
Object
Ethnic group
ABSTRACT

OBJECTIVE:

The aim of this study was to investigate the association of obesity with in-hospital coronavirus disease 2019 (COVID-19) outcomes in different ethnic groups.

METHODS:

Patients admitted to hospital with COVID-19 in the United Kingdom through the Clinical Characterisation Protocol UK (CCP-UK) developed by the International Severe Acute Respiratory and emerging Infections Consortium (ISARIC) were included from February 6 to October 12, 2020. Ethnicity was classified as White, South Asian, Black, and other minority ethnic groups. Outcomes were admission to critical care, mechanical ventilation, and in-hospital mortality, adjusted for age, sex, and chronic diseases.

RESULTS:

Of the participants included, 54,254 (age = 76 years; 45.0% women) were White, 3,728 (57 years; 41.1% women) were South Asian, 2,523 (58 years; 44.9% women) were Black, and 5,427 (61 years; 40.8% women) were other ethnicities. Obesity was associated with all outcomes in all ethnic groups, with associations strongest for black ethnicities. When stratified by ethnicity and obesity status, the odds ratios for admission to critical care, mechanical ventilation, and mortality in black ethnicities with obesity were 3.91 (3.13-4.88), 5.03 (3.94-6.63), and 1.93 (1.49-2.51), respectively, compared with White ethnicities without obesity.

CONCLUSIONS:

Obesity was associated with an elevated risk of in-hospital COVID-19 outcomes in all ethnic groups, with associations strongest in Black ethnicities.
Subject(s)

Full text: Available Collection: International databases Database: MEDLINE Document Type: Article Main subject: Respiration, Artificial / Critical Care / COVID-19 / Minority Groups / Obesity Subject: Respiration, Artificial / Critical Care / COVID-19 / Minority Groups / Obesity Type of study: Determinantes_sociais_saude / Etiology study / Clinical Practice Guide / Incidence study / Observational study / Risk factors Language: English Journal: Obesity (Silver Spring) Clinical aspect: Etiology Year: 2021

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Full text: Available Collection: International databases Database: MEDLINE Document Type: Article Main subject: Respiration, Artificial / Critical Care / COVID-19 / Minority Groups / Obesity Subject: Respiration, Artificial / Critical Care / COVID-19 / Minority Groups / Obesity Type of study: Determinantes_sociais_saude / Etiology study / Clinical Practice Guide / Incidence study / Observational study / Risk factors Language: English Journal: Obesity (Silver Spring) Clinical aspect: Etiology Year: 2021
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