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The characteristics of gastrointestinal symptoms in patients with severe COVID-19: a systematic review and meta-analysis.
Hayashi, Yuki; Wagatsuma, Kohei; Nojima, Masanori; Yamakawa, Tsukasa; Ichimiya, Tadashi; Yokoyama, Yoshihiro; Kazama, Tomoe; Hirayama, Daisuke; Nakase, Hiroshi.
  • Hayashi Y; Department of Gastroenterology and Hepatology, Sapporo Medical University of Medicine, S-1, W16, Chuoku, Sapporo, Hokkaido, 060-8543, Japan.
  • Wagatsuma K; Department of Gastroenterology and Hepatology, Sapporo Medical University of Medicine, S-1, W16, Chuoku, Sapporo, Hokkaido, 060-8543, Japan.
  • Nojima M; Center for Translational Research, The Institute of Medical Science, The University of Tokyo, Tokyo, 108-8639, Japan.
  • Yamakawa T; Department of Gastroenterology and Hepatology, Sapporo Medical University of Medicine, S-1, W16, Chuoku, Sapporo, Hokkaido, 060-8543, Japan.
  • Ichimiya T; Department of Gastroenterology and Hepatology, Sapporo Medical University of Medicine, S-1, W16, Chuoku, Sapporo, Hokkaido, 060-8543, Japan.
  • Yokoyama Y; Department of Gastroenterology and Hepatology, Sapporo Medical University of Medicine, S-1, W16, Chuoku, Sapporo, Hokkaido, 060-8543, Japan.
  • Kazama T; Department of Gastroenterology and Hepatology, Sapporo Medical University of Medicine, S-1, W16, Chuoku, Sapporo, Hokkaido, 060-8543, Japan.
  • Hirayama D; Department of Gastroenterology and Hepatology, Sapporo Medical University of Medicine, S-1, W16, Chuoku, Sapporo, Hokkaido, 060-8543, Japan.
  • Nakase H; Department of Gastroenterology and Hepatology, Sapporo Medical University of Medicine, S-1, W16, Chuoku, Sapporo, Hokkaido, 060-8543, Japan. hiropynakase@gmail.com.
J Gastroenterol ; 56(5): 409-420, 2021 05.
Article in English | MEDLINE | ID: covidwho-1147593
Semantic information from SemMedBD (by NLM)
1. Gastrointestinal symptom PROCESS_OF Patients
Subject
Gastrointestinal symptom
Predicate
PROCESS_OF
Object
Patients
2. COVID-19 PROCESS_OF Patients
Subject
COVID-19
Predicate
PROCESS_OF
Object
Patients
3. Abdominal Pain PROCESS_OF Patients
Subject
Abdominal Pain
Predicate
PROCESS_OF
Object
Patients
4. Diarrhea PROCESS_OF Patients
Subject
Diarrhea
Predicate
PROCESS_OF
Object
Patients
5. Gastrointestinal symptom PROCESS_OF Patients
Subject
Gastrointestinal symptom
Predicate
PROCESS_OF
Object
Patients
6. COVID-19 PROCESS_OF Patients
Subject
COVID-19
Predicate
PROCESS_OF
Object
Patients
7. Abdominal Pain PROCESS_OF Patients
Subject
Abdominal Pain
Predicate
PROCESS_OF
Object
Patients
8. Diarrhea PROCESS_OF Patients
Subject
Diarrhea
Predicate
PROCESS_OF
Object
Patients
ABSTRACT
Although primarily a respiratory illness, several studies have shown that COVID-19 causes elevation of liver enzymes and various gastrointestinal (GI) symptoms. The aim of this study was to undertake a systematic review and meta-analysis to determine whether the presence of gastrointestinal (GI) symptoms contributed toward COVID-19 severity, and identify the GI symptoms characteristic of severe COVID-19. We conducted a literature search of PubMed from December 1, 2019, to June 30, 2020, and identified all reports with GI symptoms reported. A meta-analysis comparing the severity of COVID-19 with the presence of liver enzyme elevation and GI symptoms was performed using RevMan version 5.4. Pooled data from 15,305 unique reverse transcriptase-polymerase chain reaction positive COVID-19 patients from 44 studies were analyzed. We found that the severe COVID-19 patients significantly had abdominal pain compared to the non-severe COVID-19 patients (OR = 2.70, 95% CI 1.17-6.27, Z = 2.32, p = 0.02, I2 = 0%) by analyzed 609 patients of 4 studies who reported both abdominal pain and COVID-19 severity. However, there was no significant difference in the incidence of diarrhea, nausea, or vomiting between the two groups. Thus, this systematic review and meta-analysis demonstrated that abdominal pain could be characteristic of severe COVID-19 infections. Compared with other viral infections that primarily infect the respiratory system, patients with COVID-19 have a slightly lower frequency of diarrheal symptoms with abdominal pain. However, to confirm this, further studies with COVID-19 patients across various countries and ethnicities are required.
Subject(s)
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Gastrointestinal Diseases / COVID-19 / Liver Type of study: Diagnostic study / Etiology study / Prognostic study / Randomized controlled trials / Reviews / Systematic review Topics: Long Covid Limits: Humans Language: English Journal: J Gastroenterol Journal subject: Gastroenterology Year: 2021 Document Type: Article Affiliation country: S00535-021-01778-z

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Gastrointestinal Diseases / COVID-19 / Liver Type of study: Diagnostic study / Etiology study / Prognostic study / Randomized controlled trials / Reviews / Systematic review Topics: Long Covid Limits: Humans Language: English Journal: J Gastroenterol Journal subject: Gastroenterology Year: 2021 Document Type: Article Affiliation country: S00535-021-01778-z