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Computational characterization of inhaled droplet transport to the nasopharynx.
Basu, Saikat.
  • Basu S; Department of Mechanical Engineering, South Dakota State University, Brookings, SD, 57007, USA. Saikat.Basu@sdstate.edu.
Sci Rep ; 11(1): 6652, 2021 03 23.
Article in English | MEDLINE | ID: covidwho-1147846
ABSTRACT
How human respiratory physiology and the transport phenomena associated with inhaled airflow in the upper airway proceed to impact transmission of SARS-CoV-2, leading to the initial infection, stays an open question. An answer can help determine the susceptibility of an individual on exposure to a COVID-2019 carrier and can also provide a preliminary projection of the still-unknown infectious dose for the disease. Computational fluid mechanics enabled tracking of respiratory transport in medical imaging-based anatomic domains shows that the regional deposition of virus-laden inhaled droplets at the initial nasopharyngeal infection site peaks for the droplet size range of approximately 2.5-19 [Formula see text]. Through integrating the numerical findings on inhaled transmission with sputum assessment data from hospitalized COVID-19 patients and earlier measurements of ejecta size distribution generated during regular speech, this study further reveals that the number of virions that may go on to establish the SARS-CoV-2 infection in a subject could merely be in the order of hundreds.
Subject(s)

Full text: Available Collection: International databases Database: MEDLINE Main subject: Nasopharynx / SARS-CoV-2 / COVID-19 Limits: Humans Language: English Journal: Sci Rep Year: 2021 Document Type: Article Affiliation country: S41598-021-85765-7

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Nasopharynx / SARS-CoV-2 / COVID-19 Limits: Humans Language: English Journal: Sci Rep Year: 2021 Document Type: Article Affiliation country: S41598-021-85765-7