Your browser doesn't support javascript.
Circulating mitochondrial DNA is an early indicator of severe illness and mortality from COVID-19.
Scozzi, Davide; Cano, Marlene; Ma, Lina; Zhou, Dequan; Zhu, Ji Hong; O'Halloran, Jane A; Goss, Charles; Rauseo, Adriana M; Liu, Zhiyi; Sahu, Sanjaya K; Peritore, Valentina; Rocco, Monica; Ricci, Alberto; Amodeo, Rachele; Aimati, Laura; Ibrahim, Mohsen; Hachem, Ramsey; Kreisel, Daniel; Mudd, Philip A; Kulkarni, Hrishikesh S; Gelman, Andrew E.
  • Scozzi D; Division of Cardiothoracic Surgery, Department of Surgery.
  • Cano M; Division of Pulmonary and Critical Care Medicine, Department of Medicine.
  • Ma L; Division of Pulmonary and Critical Care Medicine, Department of Medicine.
  • Zhou D; Division of Cardiothoracic Surgery, Department of Surgery.
  • Zhu JH; Division of Cardiothoracic Surgery, Department of Surgery.
  • O'Halloran JA; Division of Infectious Diseases, Department of Medicine; and.
  • Goss C; Division of Biostatistics, Washington University School of Medicine, St. Louis, Missouri, USA.
  • Rauseo AM; Division of Infectious Diseases, Department of Medicine; and.
  • Liu Z; Division of Cardiothoracic Surgery, Department of Surgery.
  • Sahu SK; Division of Pulmonary and Critical Care Medicine, Department of Medicine.
  • Peritore V; Division of Thoracic Surgery and.
  • Rocco M; Division of Anesthesiology, Department of Medical-Surgical Science and Translational Medicine, Sapienza University of Rome, Rome, Italy.
  • Ricci A; Division of Pulmonology, Department of Clinical and Molecular Medicine, Sapienza University of Rome, Rome, Italy.
  • Amodeo R; Laboratory Analysis-Flow Cytometry Section, Sapienza University of Rome, Rome, Italy.
  • Aimati L; Laboratory Analysis-Flow Cytometry Section, Sapienza University of Rome, Rome, Italy.
  • Ibrahim M; Division of Cardiothoracic Surgery, Department of Surgery.
  • Hachem R; Division of Thoracic Surgery and.
  • Kreisel D; Division of Pulmonary and Critical Care Medicine, Department of Medicine.
  • Mudd PA; Division of Cardiothoracic Surgery, Department of Surgery.
  • Kulkarni HS; Division of Emergency Medicine.
  • Gelman AE; Division of Pulmonary and Critical Care Medicine, Department of Medicine.
JCI Insight ; 6(4)2021 02 22.
Article in English | MEDLINE | ID: covidwho-1150281
ABSTRACT
BackgroundMitochondrial DNA (MT-DNA) are intrinsically inflammatory nucleic acids released by damaged solid organs. Whether circulating cell-free MT-DNA quantitation could be used to predict the risk of poor COVID-19 outcomes remains undetermined.MethodsWe measured circulating MT-DNA levels in prospectively collected, cell-free plasma samples from 97 subjects with COVID-19 at hospital presentation. Our primary outcome was mortality. Intensive care unit (ICU) admission, intubation, vasopressor, and renal replacement therapy requirements were secondary outcomes. Multivariate regression analysis determined whether MT-DNA levels were independent of other reported COVID-19 risk factors. Receiver operating characteristic and area under the curve assessments were used to compare MT-DNA levels with established and emerging inflammatory markers of COVID-19.ResultsCirculating MT-DNA levels were highly elevated in patients who eventually died or required ICU admission, intubation, vasopressor use, or renal replacement therapy. Multivariate regression revealed that high circulating MT-DNA was an independent risk factor for these outcomes after adjusting for age, sex, and comorbidities. We also found that circulating MT-DNA levels had a similar or superior area under the curve when compared against clinically established measures of inflammation and emerging markers currently of interest as investigational targets for COVID-19 therapy.ConclusionThese results show that high circulating MT-DNA levels are a potential early indicator for poor COVID-19 outcomes.FundingWashington University Institute of Clinical Translational Sciences COVID-19 Research Program and Washington University Institute of Clinical Translational Sciences (ICTS) NIH grant UL1TR002345.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: Severity of Illness Index / DNA, Mitochondrial / Cell-Free Nucleic Acids / COVID-19 Type of study: Cohort study / Diagnostic study / Observational study / Prognostic study Limits: Aged / Female / Humans / Male / Middle aged Language: English Year: 2021 Document Type: Article

Similar

MEDLINE

...
LILACS

LIS


Full text: Available Collection: International databases Database: MEDLINE Main subject: Severity of Illness Index / DNA, Mitochondrial / Cell-Free Nucleic Acids / COVID-19 Type of study: Cohort study / Diagnostic study / Observational study / Prognostic study Limits: Aged / Female / Humans / Male / Middle aged Language: English Year: 2021 Document Type: Article