Follow-up study on serum cholesterol profiles and potential sequelae in recovered COVID-19 patients.
BMC Infect Dis
; 21(1): 299, 2021 Mar 24.
Article
in English
| MEDLINE | ID: covidwho-1150392
ABSTRACT
BACKGROUND:
COVID-19 patients develop hypolipidemia. However, it is unknown whether lipid levels have improved and there are potential sequlae in recovered patients.OBJECTIVE:
In this follow-up study, we evaluated serum lipidemia and various physiopathological laboratory values in recovered patients.METHODS:
A 3-6 month follow-up study was performed between June 15 and September 3, 2020, to examine serum levels of laboratory values in 107 discharged COVID-19 patients (mild = 59; severe/critical = 48; diagnoses on admission). Sixty-one patients had a revisit chest CT scan. A Wilcoxon signed-rank test was used to analyze changes in laboratory values at admission and follow-up.RESULTS:
LDL-c and HDL-c levels were significantly higher at follow-up than at admission in severe/critical cases (p < 0.05). LDL-c levels were significantly higher at follow-up than at admission in mild cases (p < 0.05). Coagulation and liver functional values were significantly improved at follow-up than at admission for patients (p < 0.05). Increases in HDL-c significantly correlated with increases in numbers of white blood cells (p < 0.001) during patients' recovery. With exclusion of the subjects taking traditional Chinese medicines or cholesterol-lowering drugs, LDL-c and HDL-c levels were significantly increased at follow-up than at admission in severe/critical cases (p < 0.05). Residue lesions were observed in CT images in 72% (44 of 61) of follow-up patients.CONCLUSIONS:
Improvements of LDL-c, HDL-c, liver functions, and incomplete resolution of lung lesions were observed at 3-6 month follow-up for recovered patients, indicating that a long-term recovery process could be required and the development of sequelae such as pulmonary fibrosis could be expected in some patients.Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Cholesterol
/
COVID-19
Type of study:
Cohort study
/
Experimental Studies
/
Prognostic study
Topics:
Long Covid
Limits:
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Language:
English
Journal:
BMC Infect Dis
Journal subject:
Communicable Diseases
Year:
2021
Document Type:
Article
Similar
MEDLINE
...
LILACS
LIS