A Systematic Literature Review on COVID-19, Clinical Manifestation, Laboratory and Radiologic Features

ABSTRACT

Novel coronavirus outbreak in December 2019 leads to current pandemic condition worldwide. Severe acute respiratory syndrome coronavirus-2 known as the aetiologic agent of coronavirus disease 2019 (COVID-19). The major characterisation of COVID-19 is to involve lung and induce pneumonia, multiorgan failure, hypoxia and deat h. This systematic literature review aimed to assess the clinical manifestation and laboratory and radiologic features in patients with COVID-19. A literature review of the indexed articles in the Web of Science, PubMed, Scopus and Embase was performed to evaluate pathophysiology of COVID-19. Between 77,406 assessed COVID-19 patients, the most reported background diseases were cardiovascular and cerebrovascular disease. After fever, cough was the second most common repeated clinical feature. Furthermore, the laboratory investigations reveal that the C-reactive protein (CRP) increasing is the most common frequent laboratory finding. Chest imaging assessment indicates that bilateral involvement of the lungs is more common than unilateral involvement. Despite the fact that some of the COVID-19-infected patients are asymptomatic, the majority of patients showed a broad range of manifestation. The clinical findings help in better understanding of COVID-19 pathogenesis and patient's management. The primary concept of understanding of COVID-19 pathophysiology is necessary for reach to target therapeutics approach. According to the results, further in vivo investigations on animal models could be recommended for the treatment of COVID-19 patients in future.