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Enrichment of CCR6+ CD8+ T cells and CCL20 in the lungs of mechanically ventilated patients with COVID-19.
Saris, Anno; Reijnders, Tom D Y; Reijm, Martine; Hollander, Jolien C; de Buck, Kim; Schuurman, Alex R; Duitman, JanWillem; Heunks, Leo; Aman, Jurjan; Bogaard, Harm Jan; Nossent, Esther J; van der Poll, Tom; Bontkes, Hetty J.
  • Saris A; Center for Experimental and Molecular Medicine, Amsterdam UMC, Amsterdam, The Netherlands.
  • Reijnders TDY; Center for Experimental and Molecular Medicine, Amsterdam UMC, Amsterdam, The Netherlands.
  • Reijm M; Department of Clinical Chemistry, Medical Immunology Laboratory, Amsterdam UMC, Amsterdam, The Netherlands.
  • Hollander JC; Department of Clinical Chemistry, Medical Immunology Laboratory, Amsterdam UMC, Amsterdam, The Netherlands.
  • de Buck K; Department of Clinical Chemistry, Medical Immunology Laboratory, Amsterdam UMC, Amsterdam, The Netherlands.
  • Schuurman AR; Center for Experimental and Molecular Medicine, Amsterdam UMC, Amsterdam, The Netherlands.
  • Duitman J; Center for Experimental and Molecular Medicine, Amsterdam UMC, Amsterdam, The Netherlands.
  • Heunks L; Intensive Care Medicine, Amsterdam UMC, Amsterdam, The Netherlands.
  • Aman J; Pulmonary Medicine, Amsterdam UMC, Amsterdam, The Netherlands.
  • Bogaard HJ; Pulmonary Medicine, Amsterdam UMC, Amsterdam, The Netherlands.
  • Nossent EJ; Pulmonary Medicine, Amsterdam UMC, Amsterdam, The Netherlands.
  • van der Poll T; Center for Experimental and Molecular Medicine, Amsterdam UMC, Amsterdam, The Netherlands.
  • Bontkes HJ; Infectious Diseases, Amsterdam UMC, Amsterdam, The Netherlands.
Eur J Immunol ; 51(6): 1535-1538, 2021 06.
Article in English | MEDLINE | ID: covidwho-1151896
ABSTRACT
Despite high levels of CXCR3 ligands in mechanically ventilated COVID-19 patients, BALF CD8 T cells were not enriched in CXCR3+ cells but rather CCR6+ , likely due to high CCL20 levels in BALF, and had very high PD-1 expression. In mechanically ventilated, but not ward, patients Th-1 immunity is impaired. ​.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Respiration, Artificial / CD8-Positive T-Lymphocytes / Chemokine CCL20 / Receptors, CCR6 / SARS-CoV-2 / COVID-19 / Lung Limits: Aged / Female / Humans / Male / Middle aged Language: English Journal: Eur J Immunol Year: 2021 Document Type: Article Affiliation country: Eji.202049046

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Respiration, Artificial / CD8-Positive T-Lymphocytes / Chemokine CCL20 / Receptors, CCR6 / SARS-CoV-2 / COVID-19 / Lung Limits: Aged / Female / Humans / Male / Middle aged Language: English Journal: Eur J Immunol Year: 2021 Document Type: Article Affiliation country: Eji.202049046