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Attenuation of 7-ketocholesterol- and 7ß-hydroxycholesterol-induced oxiapoptophagy by nutrients, synthetic molecules and oils: Potential for the prevention of age-related diseases.
Nury, T; Yammine, A; Ghzaiel, I; Sassi, K; Zarrouk, A; Brahmi, F; Samadi, M; Rup-Jacques, S; Vervandier-Fasseur, D; Pais de Barros, J P; Bergas, V; Ghosh, S; Majeed, M; Pande, A; Atanasov, A; Hammami, S; Hammami, M; Mackrill, J; Nasser, B; Andreoletti, P; Cherkaoui-Malki, M; Vejux, A; Lizard, G.
  • Nury T; Team Bio-PeroxIL 'Biochemistry of the Peroxisome, Inflammation and Lipid Metabolism' (EA 7270), University Bourgogne Franche-Comté (UBFC), Inserm, Dijon, France.
  • Yammine A; Team Bio-PeroxIL 'Biochemistry of the Peroxisome, Inflammation and Lipid Metabolism' (EA 7270), University Bourgogne Franche-Comté (UBFC), Inserm, Dijon, France; Bioactive Molecules Research Laboratory, Doctoral School of Sciences and Technologies, Faculty of Sciences, Lebanese University, Fanar, Le
  • Ghzaiel I; Team Bio-PeroxIL 'Biochemistry of the Peroxisome, Inflammation and Lipid Metabolism' (EA 7270), University Bourgogne Franche-Comté (UBFC), Inserm, Dijon, France; University Monastir, Faculty of Medicine, LR12ES05, Lab-NAFS 'Nutrition - Functional Food & Vascular Health', Monastir, Tunisia.
  • Sassi K; Team Bio-PeroxIL 'Biochemistry of the Peroxisome, Inflammation and Lipid Metabolism' (EA 7270), University Bourgogne Franche-Comté (UBFC), Inserm, Dijon, France; University Tunis El Manar, Laboratory of Onco-Hematology (LR05ES05), Faculty of Medicine, 1007 Tunis, Tunisia.
  • Zarrouk A; University Monastir, Faculty of Medicine, LR12ES05, Lab-NAFS 'Nutrition - Functional Food & Vascular Health', Monastir, Tunisia; University Sousse, Faculty of Medicine, Sousse, Tunisia.
  • Brahmi F; University Abderrahmane Mira of Béjaia, Department of Food Sciences, Faculty of Natural and Life Sciences, Laboratory of Biophysics, Biochemistry, Biomathematics and Scientometry (3BS), Béjaia, Algeria.
  • Samadi M; LCPMC-A2, ICPM, Dept of Chemistry, Univ. Lorraine, Metz Technopôle, Metz, France.
  • Rup-Jacques S; LCPMC-A2, ICPM, Dept of Chemistry, Univ. Lorraine, Metz Technopôle, Metz, France.
  • Vervandier-Fasseur D; Team OCS, Institute of Molecular Chemistry of University of Burgundy (ICMUB UMR CNRS 6302), University of Bourgogne Franche-Comté, Dijon, France.
  • Pais de Barros JP; Plateforme de Lipidomique - Univ. Bourgogne Inserm UMR1231, LabEx LipSTIC, UFR des Sciences de Santé, Dijon, France.
  • Bergas V; Plateforme de Lipidomique - Univ. Bourgogne Inserm UMR1231, LabEx LipSTIC, UFR des Sciences de Santé, Dijon, France.
  • Ghosh S; Department of Chemistry, Indian Institute of Technology Delhi, Hauz Khas, New Delhi, India.
  • Majeed M; Sabinsa Corporation, 20 Lake Drive, East Windsor, NJ, USA.
  • Pande A; Sabinsa Corporation, 20 Lake Drive, East Windsor, NJ, USA.
  • Atanasov A; Department of Pharmacognosy, University of Vienna, Vienna, Austria; Ludwig Boltzmann Institute for Digital Health and Patient Safety, Medical University of Vienna, Vienna, Austria; Institute of Genetics and Animal Biotechnology of the Polish Academy of Sciences, Jastrzebiec, Poland; Institute of Neu
  • Hammami S; University Monastir, Faculty of Medicine, LR12ES05, Lab-NAFS 'Nutrition - Functional Food & Vascular Health', Monastir, Tunisia.
  • Hammami M; University Monastir, Faculty of Medicine, LR12ES05, Lab-NAFS 'Nutrition - Functional Food & Vascular Health', Monastir, Tunisia.
  • Mackrill J; Department of Physiology, School of Medicine, University College Cork, Cork, Ireland.
  • Nasser B; Laboratory of Biochemistry and Neurosciences, Department of Biology, University Hassan I, 26000 Settat, Morocco.
  • Andreoletti P; Team Bio-PeroxIL 'Biochemistry of the Peroxisome, Inflammation and Lipid Metabolism' (EA 7270), University Bourgogne Franche-Comté (UBFC), Inserm, Dijon, France.
  • Cherkaoui-Malki M; Team Bio-PeroxIL 'Biochemistry of the Peroxisome, Inflammation and Lipid Metabolism' (EA 7270), University Bourgogne Franche-Comté (UBFC), Inserm, Dijon, France.
  • Vejux A; Team Bio-PeroxIL 'Biochemistry of the Peroxisome, Inflammation and Lipid Metabolism' (EA 7270), University Bourgogne Franche-Comté (UBFC), Inserm, Dijon, France. Electronic address: anne.vejux@u-bourgogne.fr.
  • Lizard G; Team Bio-PeroxIL 'Biochemistry of the Peroxisome, Inflammation and Lipid Metabolism' (EA 7270), University Bourgogne Franche-Comté (UBFC), Inserm, Dijon, France. Electronic address: gerard.lizard@u-bourgogne.fr.
Ageing Res Rev ; 68: 101324, 2021 07.
Article in English | MEDLINE | ID: covidwho-1152265
ABSTRACT
Age-related diseases for which there are no effective treatments include cardiovascular diseases; neurodegenerative diseases such as Alzheimer's disease; eye disorders such as cataract and age-related macular degeneration; and, more recently, Severe Acute Respiratory Syndrome (SARS-CoV-2). These diseases are associated with plasma and/or tissue increases in cholesterol derivatives mainly formed by auto-oxidation 7-ketocholesterol, also known as 7-oxo-cholesterol, and 7ß-hydroxycholesterol. The formation of these oxysterols can be considered as a consequence of mitochondrial and peroxisomal dysfunction, leading to increased in oxidative stress, which is accentuated with age. 7-ketocholesterol and 7ß-hydroxycholesterol cause a specific form of cytotoxic activity defined as oxiapoptophagy, including oxidative stress and induction of death by apoptosis associated with autophagic criteria. Oxiaptophagy is associated with organelle dysfunction and in particular with mitochondrial and peroxisomal alterations involved in the induction of cell death and in the rupture of redox balance. As the criteria characterizing 7-ketocholesterol- and 7ß-hydroxycholesterol-induced cytotoxicity are often simultaneously observed in major age-related diseases (cardiovascular diseases, age-related macular degeneration, Alzheimer's disease) the involvement of these oxysterols in the pathophysiology of the latter seems increasingly likely. It is therefore important to better understand the signalling pathways associated with the toxicity of 7-ketocholesterol and 7ß-hydroxycholesterol in order to identify pharmacological targets, nutrients and synthetic molecules attenuating or inhibiting the cytotoxic activities of these oxysterols. Numerous natural cytoprotective compounds have been identified vitamins, fatty acids, polyphenols, terpenes, vegetal pigments, antioxidants, mixtures of compounds (oils, plant extracts) and bacterial enzymes. However, few synthetic molecules are able to prevent 7-ketocholesterol- and/or 7ß-hydroxycholesterol-induced cytotoxicity dimethyl fumarate, monomethyl fumarate, the tyrosine kinase inhibitor AG126, memantine, simvastatine, Trolox, dimethylsufoxide, mangafodipir and mitochondrial permeability transition pore (MPTP) inhibitors. The effectiveness of these compounds, several of which are already in use in humans, makes it possible to consider using them for the treatment of certain age-related diseases associated with increased plasma and/or tissue levels of 7-ketocholesterol and/or 7ß-hydroxycholesterol.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Limits: Humans Language: English Journal: Ageing Res Rev Journal subject: Geriatrics Year: 2021 Document Type: Article Affiliation country: J.arr.2021.101324

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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Limits: Humans Language: English Journal: Ageing Res Rev Journal subject: Geriatrics Year: 2021 Document Type: Article Affiliation country: J.arr.2021.101324