Activation of classical and alternative complement pathways in the pathogenesis of lung injury in COVID-19.

Satyam, Abhigyan; Tsokos, Maria G; Brook, Olga R; Hecht, Jonathan L; Moulton, Vaishali R; Tsokos, George C

Satyam, Abhigyan; Tsokos, Maria G; Brook, Olga R; Hecht, Jonathan L; Moulton, Vaishali R; Tsokos, George C.

Satyam A; Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, United States. Electronic address: asatyam@bidmc.harvard.edu.
Tsokos MG; Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, United States.
Brook OR; Department of Radiology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, United States.
Hecht JL; Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, United States.
Moulton VR; Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, United States.
Tsokos GC; Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, United States.

Clin Immunol ; 226: 108716, 2021 05.

Article in English | MEDLINE | ID: covidwho-1152310

ABSTRACT

ABSTRACT

Lung inflammation and damage is prominent in people infected with SARS-Cov-2 and a major determinant of morbidity and mortality. We report the deposition of complement components in the lungs of people who succumbed to COVID-19 consistent with the activation of the classical and the alternative pathways. Our study provides strong rationale for the expansion of trials involving the use of complement inhibitors to treat patients with COVID-19.

Subject(s)

COVID-19/immunology; Complement Activation/immunology; Complement Pathway, Alternative/immunology; Lung Injury/immunology; Aged; Aged, 80 and over; COVID-19/complications; Complement Inactivating Agents/pharmacology; Complement Inactivating Agents/therapeutic use; Epithelial Cells/metabolism; Epithelial Cells/pathology; Female; Humans; Immunohistochemistry; Lung/diagnostic imaging; Lung/immunology; Lung/pathology; Lung Injury/complications; Lung Injury/pathology; Lung Injury/virology; Male; Middle Aged

Keywords

COVID-19; Complement activation; Immune complexes; Lung injury; SARS-Cov-2

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Complement Activation / Complement Pathway, Alternative / Lung Injury / COVID-19 Type of study: Case report Topics: Long Covid Limits: Aged / Female / Humans / Male / Middle aged Language: English Journal: Clin Immunol Journal subject: Allergy and Immunology Year: 2021 Document Type: Article

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