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Immune memory in convalescent patients with asymptomatic or mild COVID-19.
Long, Quan-Xin; Jia, Yan-Jun; Wang, Xin; Deng, Hai-Jun; Cao, Xiao-Xia; Yuan, Jun; Fang, Liang; Cheng, Xu-Rong; Luo, Chao; He, An-Ran; Tang, Xiao-Jun; Hu, Jie-Li; Hu, Yuan; Tang, Ni; Cai, Xue-Fei; Wang, De-Qiang; Hu, Jie; Qiu, Jing-Fu; Liu, Bei-Zhong; Chen, Juan; Huang, Ai-Long.
  • Long QX; Key Laboratory of Molecular Biology on Infectious Diseases, Ministry of Education, Chongqing Medical University, Chongqing, 400016, China.
  • Jia YJ; Department of Endocrinology and Metabolism, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, 400010, China.
  • Wang X; Key Laboratory of Molecular Biology on Infectious Diseases, Ministry of Education, Chongqing Medical University, Chongqing, 400016, China.
  • Deng HJ; Key Laboratory of Molecular Biology on Infectious Diseases, Ministry of Education, Chongqing Medical University, Chongqing, 400016, China.
  • Cao XX; Key Laboratory of Molecular Biology on Infectious Diseases, Ministry of Education, Chongqing Medical University, Chongqing, 400016, China.
  • Yuan J; Key Laboratory of Molecular Biology on Infectious Diseases, Ministry of Education, Chongqing Medical University, Chongqing, 400016, China.
  • Fang L; Yongchuan Hospital Affiliated to Chongqing Medical University, Chongqing, 402160, China.
  • Cheng XR; Yongchuan Hospital Affiliated to Chongqing Medical University, Chongqing, 402160, China.
  • Luo C; Wanzhou District Center for Disease Control and Prevention, Chongqing, 404100, China.
  • He AR; Wanzhou District Center for Disease Control and Prevention, Chongqing, 404100, China.
  • Tang XJ; School of Public Health and Management, Chongqing Medical University, Chongqing, 400016, China.
  • Hu JL; Key Laboratory of Molecular Biology on Infectious Diseases, Ministry of Education, Chongqing Medical University, Chongqing, 400016, China.
  • Hu Y; Key Laboratory of Molecular Biology on Infectious Diseases, Ministry of Education, Chongqing Medical University, Chongqing, 400016, China.
  • Tang N; Key Laboratory of Molecular Biology on Infectious Diseases, Ministry of Education, Chongqing Medical University, Chongqing, 400016, China.
  • Cai XF; Key Laboratory of Molecular Biology on Infectious Diseases, Ministry of Education, Chongqing Medical University, Chongqing, 400016, China.
  • Wang DQ; Key Laboratory of Molecular Biology on Infectious Diseases, Ministry of Education, Chongqing Medical University, Chongqing, 400016, China.
  • Hu J; Key Laboratory of Molecular Biology on Infectious Diseases, Ministry of Education, Chongqing Medical University, Chongqing, 400016, China.
  • Qiu JF; School of Public Health and Management, Chongqing Medical University, Chongqing, 400016, China.
  • Liu BZ; Yongchuan Hospital Affiliated to Chongqing Medical University, Chongqing, 402160, China.
  • Chen J; Key Laboratory of Molecular Biology on Infectious Diseases, Ministry of Education, Chongqing Medical University, Chongqing, 400016, China. chenjuan2014@cqmu.edu.cn.
  • Huang AL; Key Laboratory of Molecular Biology on Infectious Diseases, Ministry of Education, Chongqing Medical University, Chongqing, 400016, China. ahuang@cqmu.edu.cn.
Cell Discov ; 7(1): 18, 2021 Mar 25.
Article in English | MEDLINE | ID: covidwho-1152838
ABSTRACT
It is important to evaluate the durability of the protective immune response elicited by primary infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Here, we systematically evaluated the SARS-CoV-2-specific memory B cell and T cell responses in healthy controls and individuals recovered from asymptomatic or symptomatic infection approximately 6 months prior. Comparatively low frequencies of memory B cells specific for the receptor-binding domain (RBD) of spike glycoprotein (S) persisted in the peripheral blood of individuals who recovered from infection (median 0.62%, interquartile range 0.48-0.69). The SARS-CoV-2 RBD-specific memory B cell response was detected in 2 of 13 individuals who recovered from asymptomatic infection and 10 of 20 individuals who recovered from symptomatic infection. T cell responses induced by S, membrane (M), and nucleocapsid (N) peptide libraries from SARS-CoV-2 were observed in individuals recovered from coronavirus disease 2019 (COVID-19), and cross-reactive T cell responses to SARS-CoV-2 were also detected in healthy controls.

Full text: Available Collection: International databases Database: MEDLINE Type of study: Experimental Studies / Randomized controlled trials Topics: Long Covid Language: English Journal: Cell Discov Year: 2021 Document Type: Article Affiliation country: S41421-021-00250-9

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Experimental Studies / Randomized controlled trials Topics: Long Covid Language: English Journal: Cell Discov Year: 2021 Document Type: Article Affiliation country: S41421-021-00250-9