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Towards Optimization of Hydroxychloroquine Dosing in Intensive Care Unit COVID-19 Patients.
Perinel, Sophie; Launay, Manon; Botelho-Nevers, Élisabeth; Diconne, Éric; Louf-Durier, Aurore; Lachand, Raphaël; Murgier, Martin; Page, Dominique; Vermesch, Régine; Thierry, Guillaume; Delavenne, Xavier.
  • Perinel S; Service de Médecine Intensive et Réanimation, Centre Hospitalier Universitaire (CHU) de Saint-Etienne, France.
  • Launay M; Institut National de la Santé et de la Recherche Médicale U1059, Dysfonctions Vasculaires et de L'Hémostase, Université de Lyon, Saint-Etienne, France.
  • Botelho-Nevers É; Laboratoire de Pharmacologie, Toxicologie, Gaz du Sang, CHU de Saint-Etienne, France.
  • Diconne É; Infectious Diseases Department, CHU de Saint-Etienne, France.
  • Louf-Durier A; Service de Médecine Intensive et Réanimation, Centre Hospitalier Universitaire (CHU) de Saint-Etienne, France.
  • Lachand R; Service de Médecine Intensive et Réanimation, Centre Hospitalier Universitaire (CHU) de Saint-Etienne, France.
  • Murgier M; Service de Médecine Intensive et Réanimation, Centre Hospitalier Universitaire (CHU) de Saint-Etienne, France.
  • Page D; Service de Médecine Intensive et Réanimation, Centre Hospitalier Universitaire (CHU) de Saint-Etienne, France.
  • Vermesch R; Service de Médecine Intensive et Réanimation, Centre Hospitalier Universitaire (CHU) de Saint-Etienne, France.
  • Thierry G; Service de Médecine Intensive et Réanimation, Centre Hospitalier Universitaire (CHU) de Saint-Etienne, France.
  • Delavenne X; Service de Médecine Intensive et Réanimation, Centre Hospitalier Universitaire (CHU) de Saint-Etienne, France.
Clin Infect Dis ; 71(16): 2227-2229, 2020 11 19.
Article in English | MEDLINE | ID: covidwho-1153141
ABSTRACT
Hydroxychloroquine (HCQ) appears to be a promising treatment for COVID-19. However, all ongoing clinical trials with HCQ use different dosing regimens, resulting in various concentrations. Pharmacokinetic studies are therefore needed to define the optimal dosing regimen.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Drug Treatment / Hydroxychloroquine Type of study: Cohort study / Observational study / Prognostic study Limits: Adult / Aged / Female / Humans / Male / Middle aged Country/Region as subject: Europa Language: English Journal: Clin Infect Dis Journal subject: Communicable Diseases Year: 2020 Document Type: Article Affiliation country: Cid

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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Drug Treatment / Hydroxychloroquine Type of study: Cohort study / Observational study / Prognostic study Limits: Adult / Aged / Female / Humans / Male / Middle aged Country/Region as subject: Europa Language: English Journal: Clin Infect Dis Journal subject: Communicable Diseases Year: 2020 Document Type: Article Affiliation country: Cid