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Chloroquine Inhibits the Release of Inflammatory Cytokines by Human Lung Explants.
Grassin-Delyle, Stanislas; Salvator, Hélène; Brollo, Marion; Catherinot, Emilie; Sage, Edouard; Couderc, Louis-Jean; Naline, Emmanuel; Devillier, Philippe.
  • Grassin-Delyle S; Department of Respiratory Diseases, Foch Hospital, Suresnes, France.
  • Salvator H; INSERM Infection and Inflammation, Département de Biotechnologie de la Santé, University Paris-Saclay, Montigny-le-Bretonneux, France.
  • Brollo M; Department of Respiratory Diseases, Foch Hospital, Suresnes, France.
  • Catherinot E; Laboratory of Research in Respiratory Pharmacology, Exhalomics Facility, Foch Hospital, University Paris-Saclay, Suresnes, France.
  • Sage E; Laboratory of Research in Respiratory Pharmacology, Exhalomics Facility, Foch Hospital, University Paris-Saclay, Suresnes, France.
  • Couderc LJ; Department of Respiratory Diseases, Foch Hospital, Suresnes, France.
  • Naline E; Department of Respiratory Diseases, Foch Hospital, Suresnes, France.
  • Devillier P; UMR0892, INR AE, University Paris-Saclay, Jouy-en-Josas, France.
Clin Infect Dis ; 71(16): 2265-2268, 2020 11 19.
Article in English | MEDLINE | ID: covidwho-1153158
ABSTRACT
On human lung parenchymal explants, chloroquine concentration clinically achievable in the lung (100 µM) inhibited the lipopolysaccharide-induced release of TNF-ɑ (by 76%), IL-6 (by 68%), CCL2 (by 72%), and CCL3 (by 67%). Besides its antiviral activity, chloroquine might also mitigate the cytokine storm associated with severe pneumonia caused by coronaviruses.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Chloroquine / Cytokines Type of study: Prognostic study Limits: Humans Language: English Journal: Clin Infect Dis Journal subject: Communicable Diseases Year: 2020 Document Type: Article Affiliation country: Cid

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Chloroquine / Cytokines Type of study: Prognostic study Limits: Humans Language: English Journal: Clin Infect Dis Journal subject: Communicable Diseases Year: 2020 Document Type: Article Affiliation country: Cid