Single Dose of an mRNA Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-Cov-2) Vaccine Is Associated With Lower Nasopharyngeal Viral Load Among Nursing Home Residents With Asymptomatic Coronavirus Disease 2019 (COVID-19).

McEllistrem, M Catherine; Clancy, Cornelius J; Buehrle, Deanna J; Lucas, Aaron; Decker, Brooke K

McEllistrem, M Catherine; Clancy, Cornelius J; Buehrle, Deanna J; Lucas, Aaron; Decker, Brooke K.

McEllistrem MC; Department of Medicine, Infectious Diseases Section, VA Pittsburgh Healthcare System, Pittsburgh, Pennsylvania, USA.
Clancy CJ; Department of Medicine, Infectious Diseases Section, VA Pittsburgh Healthcare System, Pittsburgh, Pennsylvania, USA.
Buehrle DJ; Department of Medicine, Division of Infectious Diseases, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Lucas A; Department of Medicine, Infectious Diseases Section, VA Pittsburgh Healthcare System, Pittsburgh, Pennsylvania, USA.
Decker BK; Department of Medicine, Infectious Diseases Section, VA Pittsburgh Healthcare System, Pittsburgh, Pennsylvania, USA.

Clin Infect Dis ; 73(6): e1365-e1367, 2021 09 15.

Article in English | MEDLINE | ID: covidwho-1413083

ABSTRACT

ABSTRACT

In nursing home residents with asymptomatic COVID-19 diagnosed through twice-weekly surveillance testing, single-dose BNT162b2 vaccination (Pfizer-BioNTech) was associated with -2.4 mean log10 lower nasopharyngeal viral load than detected in absence of vaccination (Pâ=â.004). Since viral load is linked to transmission, single-dose mRNA SARS-CoV-2 vaccination may help control outbreaks.

Subject(s)

COVID-19; SARS-CoV-2; BNT162 Vaccine; COVID-19 Vaccines; Humans; Nursing Homes; RNA, Messenger; Viral Load

Keywords

COVID-19; SARS-CoV-2; asymptomatic; cycle threshold; viral load

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Full text: Available Collection: International databases Database: MEDLINE Main subject: SARS-CoV-2 / COVID-19 Topics: Vaccines Limits: Humans Language: English Journal: Clin Infect Dis Journal subject: Communicable Diseases Year: 2021 Document Type: Article Affiliation country: Cid

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