Your browser doesn't support javascript.
Animal Hosts and Experimental Models of SARS-CoV-2 Infection.
Parolin, Cristina; Virtuoso, Sara; Giovanetti, Marta; Angeletti, Silvia; Ciccozzi, Massimo; Borsetti, Alessandra.
  • Parolin C; Department of Molecular Medicine, University of Padova, Padova, Italy.
  • Virtuoso S; National HIV/AIDS Research Center, Istituto Superiore di Sanità, Rome, Italy.
  • Giovanetti M; Reference Laboratory of Flavivirus, Oswaldo Cruz Institute, Fundação Oswaldo Cruz, Rio de Janeiro, Brazil.
  • Angeletti S; Unit of Clinical Laboratory Science, University Campus Bio-Medico of Rome, Rome, Italy.
  • Ciccozzi M; Medical Statistics and Molecular Epidemiology, University Campus Bio-Medico of Rome, Rome, Italy.
  • Borsetti A; National HIV/AIDS Research Center, Istituto Superiore di Sanità, Rome, Italy.
Chemotherapy ; 66(1-2): 8-16, 2021.
Article in English | MEDLINE | ID: covidwho-1153760
ABSTRACT
Viruses arise through cross-species transmission and can cause potentially fatal diseases in humans. This is the case of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) which recently appeared in Wuhan, China, and rapidly spread worldwide, causing the outbreak of coronavirus disease 2019 (COVID-19) and posing a global health emergency. Sequence analysis and epidemiological investigations suggest that the most likely original source of SARS-CoV-2 is a spillover from an animal reservoir, probably bats, that infected humans either directly or through intermediate animal hosts. The role of animals as reservoirs and natural hosts in SARS-CoV-2 has to be explored, and animal models for COVID-19 are needed as well to be evaluated for countermeasures against SARS-CoV-2 infection. Experimental cells, tissues, and animal models that are currently being used and developed in COVID-19 research will be presented.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: Disease Reservoirs / Communicable Disease Control / Disease Vectors / SARS-CoV-2 / COVID-19 Type of study: Experimental Studies / Observational study / Randomized controlled trials Limits: Animals / Humans Language: English Journal: Chemotherapy Year: 2021 Document Type: Article Affiliation country: 000515341

Similar

MEDLINE

...
LILACS

LIS


Full text: Available Collection: International databases Database: MEDLINE Main subject: Disease Reservoirs / Communicable Disease Control / Disease Vectors / SARS-CoV-2 / COVID-19 Type of study: Experimental Studies / Observational study / Randomized controlled trials Limits: Animals / Humans Language: English Journal: Chemotherapy Year: 2021 Document Type: Article Affiliation country: 000515341