The interplay between environmental exposures and COVID-19 risks in the health of children.
Environ Health
; 20(1): 34, 2021 03 26.
Article
in English
| MEDLINE | ID: covidwho-1154012
ABSTRACT
BACKGROUND:
An unusual feature of SARS-Cov-2 infection and the COVID-19 pandemic is that children are less severely affected than adults. This is especially paradoxical given the epidemiological links between poor air quality and increased COVID-19 severity in adults and that children are generally more vulnerable than adults to the adverse consequences of air pollution.OBJECTIVES:
To identify gaps in knowledge about the factors that protect children from severe SARS-Cov-2 infection even in the face of air pollution, and to develop a transdisciplinary research strategy to address these gaps.METHODS:
An international group of researchers interested in children's environmental health was invited to identify knowledge gaps and to develop research questions to close these gaps.DISCUSSION:
Key research questions identified include what are the effects of SAR-Cov-2 infection during pregnancy on the developing fetus and child; what is the impact of age at infection and genetic susceptibility on disease severity; why do some children with COVID-19 infection develop toxic shock and Kawasaki-like symptoms; what are the impacts of toxic environmental exposures including poor air quality, chemical and metal exposures on innate immunity, especially in the respiratory epithelium; what is the possible role of a "dirty" environment in conveying protection - an example of the "hygiene hypothesis"; and what are the long term health effects of SARS-Cov-2 infection in early life.CONCLUSION:
A concerted research effort by a multidisciplinary team of scientists is needed to understand the links between environmental exposures, especially air pollution and COVID-19. We call for specific research funding to encourage basic and clinical research to understand if/why exposure to environmental factors is associated with more severe disease, why children appear to be protected, and how innate immune responses may be involved. Lessons learned about SARS-Cov-2 infection in our children will help us to understand and reduce disease severity in adults, the opposite of the usual scenario.Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Environmental Health
/
Child Health
/
Environmental Exposure
/
COVID-19
Type of study:
Observational study
/
Prognostic study
Topics:
Long Covid
Limits:
Adult
/
Child
/
Humans
Language:
English
Journal:
Environ Health
Journal subject:
Environmental Health
Year:
2021
Document Type:
Article
Affiliation country:
S12940-021-00716-z
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