Your browser doesn't support javascript.
COVID-19 Seroprevalence among Healthcare Workers of a Large COVID-19 Hospital in Rome Reveals Strengths and Limits of Two Different Serological Tests.
Vetrugno, Giuseppe; La Milia, Daniele Ignazio; D'Ambrosio, Floriana; Di Pumpo, Marcello; Pastorino, Roberta; Boccia, Stefania; Ricci, Rosalba; De-Giorgio, Fabio; Cicconi, Michela; Foti, Federica; Pascucci, Domenico; Castrini, Francesco; Carini, Elettra; Cambieri, Andrea; D'Alfonso, Maria Elena; Capalbo, Gennaro; Fantoni, Massimo; Moscato, Umberto; Staiti, Domenico; De Simone, Francesco Maria; Berloco, Filippo; Damiani, Gianfranco; Zega, Maurizio; Cattani, Paola; Posteraro, Brunella; Sanguinetti, Maurizio; Laurenti, Patrizia.
  • Vetrugno G; Risk Management Unit, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, Italy.
  • La Milia DI; Section of Legal Medicine, Department of Health Care Surveillance and Bioethics, Università Cattolica del Sacro Cuore, 00168 Rome, Italy.
  • D'Ambrosio F; Hospital Health Management, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, Italy.
  • Di Pumpo M; Section of Hygiene, University Department of Health Sciences and Public Health, Università Cattolica del Sacro Cuore, 00168 Rome, Italy.
  • Pastorino R; Section of Hygiene, University Department of Health Sciences and Public Health, Università Cattolica del Sacro Cuore, 00168 Rome, Italy.
  • Boccia S; Department of Woman and Child Health and Public Health-Public Health Area, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, Italy.
  • Ricci R; Section of Hygiene, University Department of Health Sciences and Public Health, Università Cattolica del Sacro Cuore, 00168 Rome, Italy.
  • De-Giorgio F; Department of Woman and Child Health and Public Health-Public Health Area, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, Italy.
  • Cicconi M; Department of Laboratory and Infectivological Sciences, Fondazione Policlinico A. Gemelli IRCCS, 00168 Rome, Italy.
  • Foti F; Section of Legal Medicine, Department of Health Care Surveillance and Bioethics, Università Cattolica del Sacro Cuore, 00168 Rome, Italy.
  • Pascucci D; Risk Management Unit, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, Italy.
  • Castrini F; Risk Management Unit, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, Italy.
  • Carini E; Section of Hygiene, University Department of Health Sciences and Public Health, Università Cattolica del Sacro Cuore, 00168 Rome, Italy.
  • Cambieri A; Department of Woman and Child Health and Public Health-Public Health Area, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, Italy.
  • D'Alfonso ME; Section of Hygiene, University Department of Health Sciences and Public Health, Università Cattolica del Sacro Cuore, 00168 Rome, Italy.
  • Capalbo G; Section of Hygiene, University Department of Health Sciences and Public Health, Università Cattolica del Sacro Cuore, 00168 Rome, Italy.
  • Fantoni M; Hospital Health Management, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, Italy.
  • Moscato U; Hospital Health Management, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, Italy.
  • Staiti D; Hospital Health Management, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, Italy.
  • De Simone FM; Department of Laboratory and Infectivological Sciences, Fondazione Policlinico A. Gemelli IRCCS, 00168 Rome, Italy.
  • Berloco F; Section of Infectious Diseases, Department of Health Care Surveillance and Bioethics, Università Cattolica del Sacro Cuore, 00168 Rome, Italy.
  • Damiani G; Section of Hygiene, University Department of Health Sciences and Public Health, Università Cattolica del Sacro Cuore, 00168 Rome, Italy.
  • Zega M; Department of Woman and Child Health and Public Health-Public Health Area, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, Italy.
  • Cattani P; Department of Woman and Child Health and Public Health-Public Health Area, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, Italy.
  • Posteraro B; Occupational Health Section, University Department of Health Sciences and Public Health, Università Cattolica del Sacro Cuore, 00168 Rome, Italy.
  • Sanguinetti M; Department of Woman and Child Health and Public Health-Public Health Area, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, Italy.
  • Laurenti P; Hospital Health Management, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, Italy.
Int J Environ Res Public Health ; 18(5)2021 03 06.
Article in English | MEDLINE | ID: covidwho-1154372
ABSTRACT
Healthcare workers are at the forefront against COVID-19, worldwide. Since Fondazione Policlinico Universitario A. Gemelli (FPG) IRCCS was enlisted as a COVID-19 hospital, the healthcare workers deployed to COVID-19 wards were separated from those with limited/no exposure, whereas the administrative staff were designated to work from home. Between 4 June and 3 July 2020, an investigation was conducted to evaluate the seroprevalence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) immunoglobulin (IgG) antibodies among the employees of the FPG using point-of-care (POC) and venous blood tests. Sensitivity, specificity, and predictive values were determined with reverse-transcription polymerase chain reaction on nasal/oropharyngeal swabs as the diagnostic gold standard. The participants enrolled amounted to 4777. Seroprevalence was 3.66% using the POC test and 1.19% using the venous blood test, with a significant difference (p < 0.05). The POC test sensitivity and specificity were, respectively, 63.64% (95% confidence interval (CI) 62.20% to 65.04%) and 96.64% (95% CI 96.05% to 97.13%), while those of the venous blood test were, respectively, 78.79% (95% CI 77.58% to 79.94%) and 99.36% (95% CI 99.07% to 99.55%). Among the low-risk populations, the POC test's predictive values were 58.33% (positive) and 98.23% (negative), whereas those of the venous blood test were 92.86% (positive) and 98.53% (negative). According to our study, these serological tests cannot be a valid alternative to diagnose COVID-19 infection in progress.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Type of study: Diagnostic study / Experimental Studies / Observational study / Prognostic study Limits: Humans Country/Region as subject: Europa Language: English Year: 2021 Document Type: Article Affiliation country: Ijerph18052650

Similar

MEDLINE

...
LILACS

LIS


Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Type of study: Diagnostic study / Experimental Studies / Observational study / Prognostic study Limits: Humans Country/Region as subject: Europa Language: English Year: 2021 Document Type: Article Affiliation country: Ijerph18052650