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Prevention of Covid-19 Infection and Related Complications by Ozonized Oils.
Izzotti, Alberto; Fracchia, Enzo; Au, William; Colombo, Monica; Pfeffer, Ulrich; Emionite, Laura; Pavan, Simone; Miotto, Daniele; Lova, Paola; Grasselli, Elena; Faelli, Emanuela; Piero, Ruggeri; Tiso, Micaela; Pulliero, Alessandra.
  • Izzotti A; Department of Experimental Medicine, University of Genoa, 16132 Genoa, Italy.
  • Fracchia E; IRCCS Ospedale Policlinico San Martino, 16132 Genoa, Italy.
  • Au W; Galliera Hospital, 16132 Genoa, Italy.
  • Colombo M; Faculty of Medicine, Pharmacy, Science and Technology, The George Emil Palade University, 540142 Targu Mures, Romania.
  • Pfeffer U; IRCCS Ospedale Policlinico San Martino, 16132 Genoa, Italy.
  • Emionite L; IRCCS Ospedale Policlinico San Martino, 16132 Genoa, Italy.
  • Pavan S; IRCCS Ospedale Policlinico San Martino, 16132 Genoa, Italy.
  • Miotto D; BWH Graphic Solutions, 28001 Madrid, Spain.
  • Lova P; BWH Graphic Solutions, 28001 Madrid, Spain.
  • Grasselli E; Department of Chemistry and Industrial Chemistry, University of Genoa, 16132 Genoa, Italy.
  • Faelli E; Department of Earth Sciences, University of Genoa, 16132 Genoa, Italy.
  • Piero R; Department of Experimental Medicine, University of Genoa, 16132 Genoa, Italy.
  • Tiso M; Department of Experimental Medicine, University of Genoa, 16132 Genoa, Italy.
  • Pulliero A; MICAMO Spin-Off Department of Earth Sciences, University of Genoa, 16132 Genoa, Italy.
J Pers Med ; 11(3)2021 Mar 22.
Article in English | MEDLINE | ID: covidwho-1154441
Semantic information from SemMedBD (by NLM)
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ABSTRACT

BACKGROUND:

The COVID-19 pandemic continues to ravage the human population; therefore, multiple prevention and intervention protocols are being rapidly developed. The aim of our study was to develop a new chemo-prophylactic/-therapeutic strategy that effectively prevents COVID-19 and related complications.

METHODS:

In in vitro studies, COVID-19 infection-sensitive cells were incubated with human oropharyngeal fluids containing high SARS-CoV-2 loads. Levels of infection were determined via intra-cellular virus loads using quantitative PCR (qPCR). Efficacies for infection prevention were determined using several antiviral treatments lipid-encapsulated ozonized oil (HOO), water-soluble HOO (HOOws), UV, and hydrogen peroxide. In in vivo studies, safety and efficacy of HOO in fighting COVID-19 infection was evaluated in human subjects.

RESULTS:

HOO in combination with HOOws was the only treatment able to fully neutralize SARS-CoV-2 as well as its capacity to penetrate and reproduce inside sensitive cells. Accordingly, the feasibility of using HOO/HOOws was tested in vivo. Analysis of expired gas in healthy subjects indicates that HOO administration increases oxygen availability in the lung. For our human studies, HOO/HOOws was administered to 52 cancer patients and 21 healthy subjects at high risk for COVID-19 infection, and all of them showed clinical safety. None of them developed COVID-19 infection, although an incidence of at least 11 cases was expected. Efficacy of HOO/HOOws was tested in four COVID-19 patients obtaining recovery and qPCR negativization in less than 10 days.

CONCLUSIONS:

Based on our experience, the HOO/HOOws treatment can be administered at standard doses (three pills per day) for chemo-prophylactic purposes to healthy subjects for COVID-19 prevention and at high doses (up to eight pills per day) for therapeutic purposes to infected patients. This combined prevention strategy can provide a novel protocol to fight the COVID-19 pandemic.
Keywords

Full text: Available Collection: International databases Database: MEDLINE Type of study: Experimental Studies / Observational study / Prognostic study Topics: Vaccines Language: English Year: 2021 Document Type: Article Affiliation country: Jpm11030226

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Experimental Studies / Observational study / Prognostic study Topics: Vaccines Language: English Year: 2021 Document Type: Article Affiliation country: Jpm11030226