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Bioinformatic Analysis of Genome-Predicted Bat Cathelicidins.
Pérez de la Lastra, José Manuel; Asensio-Calavia, Patricia; González-Acosta, Sergio; Baca-González, Victoria; Morales-delaNuez, Antonio.
  • Pérez de la Lastra JM; Biotechnology of Macromolecules Research Group, Instituto de Productos Naturales y Agrobiología, (IPNA-CSIC), Avda. Astrofísico Francisco Sánchez, 3, 38206 San Cristóbal de la Laguna, Spain.
  • Asensio-Calavia P; Biological Activity Service, Instituto de Productos Naturales y Agrobiología, (IPNA-CSIC), Avda. Astrofísico Francisco Sánchez, 3, 38206 San Cristóbal de la Laguna, Spain.
  • González-Acosta S; Biotechnology of Macromolecules Research Group, Instituto de Productos Naturales y Agrobiología, (IPNA-CSIC), Avda. Astrofísico Francisco Sánchez, 3, 38206 San Cristóbal de la Laguna, Spain.
  • Baca-González V; Biotechnology of Macromolecules Research Group, Instituto de Productos Naturales y Agrobiología, (IPNA-CSIC), Avda. Astrofísico Francisco Sánchez, 3, 38206 San Cristóbal de la Laguna, Spain.
  • Morales-delaNuez A; Biotechnology of Macromolecules Research Group, Instituto de Productos Naturales y Agrobiología, (IPNA-CSIC), Avda. Astrofísico Francisco Sánchez, 3, 38206 San Cristóbal de la Laguna, Spain.
Molecules ; 26(6)2021 Mar 23.
Article in English | MEDLINE | ID: covidwho-1154456
Semantic information from SemMedBD (by NLM)
1. Cathelicidins PART_OF Chiroptera
Subject
Cathelicidins
Predicate
PART_OF
Object
Chiroptera
2. 2019 novel coronavirus INTERACTS_WITH COVID-19
Subject
2019 novel coronavirus
Predicate
INTERACTS_WITH
Object
COVID-19
3. Cathelicidins PART_OF Chiroptera
Subject
Cathelicidins
Predicate
PART_OF
Object
Chiroptera
4. 2019 novel coronavirus INTERACTS_WITH COVID-19
Subject
2019 novel coronavirus
Predicate
INTERACTS_WITH
Object
COVID-19
ABSTRACT
Bats are unique in their potential to serve as reservoir hosts for intracellular pathogens. Recently, the impact of COVID-19 has relegated bats from biomedical darkness to the frontline of public health as bats are the natural reservoir of many viruses, including SARS-Cov-2. Many bat genomes have been sequenced recently, and sequences coding for antimicrobial peptides are available in the public databases. Here we provide a structural analysis of genome-predicted bat cathelicidins as components of their innate immunity. A total of 32 unique protein sequences were retrieved from the NCBI database. Interestingly, some bat species contained more than one cathelicidin. We examined the conserved cysteines within the cathelin-like domain and the peptide portion of each sequence and revealed phylogenetic relationships and structural dissimilarities. The antibacterial, antifungal, and antiviral activity of peptides was examined using bioinformatic tools. The peptides were modeled and subjected to docking analysis with the region binding domain (RBD) region of the SARS-CoV-2 Spike protein. The appearance of multiple forms of cathelicidins verifies the complex microbial challenges encountered by these species. Learning more about antiviral defenses of bats and how they drive virus evolution will help scientists to investigate the function of antimicrobial peptides in these species.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Chiroptera / Cathelicidins / Spike Glycoprotein, Coronavirus Type of study: Prognostic study / Risk factors Limits: Animals Language: English Journal subject: Biology Year: 2021 Document Type: Article Affiliation country: Molecules26061811

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Chiroptera / Cathelicidins / Spike Glycoprotein, Coronavirus Type of study: Prognostic study / Risk factors Limits: Animals Language: English Journal subject: Biology Year: 2021 Document Type: Article Affiliation country: Molecules26061811