Prognostic factors in patients with advanced cancer and COVID-19: a cohort from the Palliative Care Unit of the Brazilian National Cancer Institute.
Support Care Cancer
; 29(10): 6005-6012, 2021 Oct.
Article
in English
| MEDLINE | ID: covidwho-1155278
ABSTRACT
OBJECTIVE:
To describe overall survival (OS) in 90 days and to evaluate the prognostic factors in patients with advanced cancer and COVID-19.METHODS:
This is a retrospective cohort study carried out at the Palliative Care Unit of the Brazilian National Cancer Institute. Patients with advanced cancer and COVID-19 confirmed by Reverse Transcription Polymerase Chain Reaction were included. Kaplan-Meier's curves, log-rank test, and Cox regression were performed.RESULTS:
Eighty-three inpatients were selected. The average age was 61.4 (±12.6) years, with a higher proportion of women (73.4%). The most prevalent tumor type was breast (36.7%), followed by gastrointestinal tract (20.3%). The OS was 32 [interquartile range (IQR) 6-70] days, and at the end of the follow-up period, 17 patients (20.5%) were alive and 66 (79.5%) had died. Patients with advanced cancer and COVID-19 and who were 60-74 years old [hazard ratio (HR) 2.03; 95% confidence interval (CI) 1.09-3.78], with lung tumors (HR 17.50; 95% CI 1.70-28.34), with lung metastasis (HR 4.21; 95% CI 2.17-8.15), and with chronic obstructive pulmonary disease (HR 4.92; 95% CI 1.01-24.69) had higher risk of death in 90 days.CONCLUSION:
The age of 60-74 years old, lung tumors (primary or metastases), and the presence of chronic obstructive pulmonary disease were considered independent prognostic factors in patients with advanced cancer and COVID-19.Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
COVID-19
/
Lung Neoplasms
Type of study:
Cohort study
/
Experimental Studies
/
Observational study
/
Prognostic study
Limits:
Aged
/
Female
/
Humans
/
Middle aged
Country/Region as subject:
North America
/
South America
/
Brazil
Language:
English
Journal:
Support Care Cancer
Journal subject:
Neoplasms
/
Health Services
Year:
2021
Document Type:
Article
Affiliation country:
S00520-021-06149-1
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