Your browser doesn't support javascript.
Asthma in patients with suspected and diagnosed coronavirus disease 2019.
Cao, Lijuan; Lee, Sandra; Krings, James G; Rauseo, Adriana M; Reynolds, Daniel; Presti, Rachel; Goss, Charles; Mudd, Philip A; O'Halloran, Jane A; Wang, Leyao.
  • Cao L; Division of Allergy and Immunology, Department of Medicine, Washington University School of Medicine in St Louis, St Louis, Missouri.
  • Lee S; Division of Allergy and Immunology, Department of Medicine, Washington University School of Medicine in St Louis, St Louis, Missouri.
  • Krings JG; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Washington University School of Medicine in St Louis, St Louis, Missouri.
  • Rauseo AM; Division of Infectious Diseases, Department of Medicine, Washington University School of Medicine in St Louis, St Louis, Missouri.
  • Reynolds D; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Washington University School of Medicine in St Louis, St Louis, Missouri.
  • Presti R; Division of Infectious Diseases, Department of Medicine, Washington University School of Medicine in St Louis, St Louis, Missouri.
  • Goss C; Division of Biostatistics, Washington University School of Medicine in St Louis, St Louis, Missouri.
  • Mudd PA; Department of Emergency Medicine, Washington University School of Medicine in St Louis, St Louis, Missouri.
  • O'Halloran JA; Division of Infectious Diseases, Department of Medicine, Washington University School of Medicine in St Louis, St Louis, Missouri.
  • Wang L; Division of Allergy and Immunology, Department of Medicine, Washington University School of Medicine in St Louis, St Louis, Missouri. Electronic address: Leyao.wang@wustl.edu.
Ann Allergy Asthma Immunol ; 126(5): 535-541.e2, 2021 05.
Article in English | MEDLINE | ID: covidwho-1155396
ABSTRACT

BACKGROUND:

Patients with asthma are comparatively susceptible to respiratory viral infections and more likely to develop severe symptoms than people without asthma. During the coronavirus disease 2019 (COVID-19) pandemic, it is necessary to adequately evaluate the characteristics and outcomes of the population with asthma in the population tested for and diagnosed as having COVID-19.

OBJECTIVE:

To perform a study to assess the impact of asthma on COVID-19 diagnosis, presenting symptoms, disease severity, and cytokine profiles.

METHODS:

This was an analysis of a prospectively collected cohort of patients suspected of having COVID-19 who presented for COVID-19 testing at a tertiary medical center in Missouri between March 2020 and September 2020. We classified and analyzed patients according to their pre-existing asthma diagnosis and subsequent COVID-19 testing results.

RESULTS:

Patients suspected of having COVID-19 (N = 435) were enrolled in this study. The proportions of patients testing positive for COVID-19 were 69.2% and 81.9% in the groups with asthma and without asthma, respectively. The frequencies of relevant symptoms were similar between the groups with asthma with positive and negative COVID-19 test results. In the population diagnosed as having COVID-19 (n = 343), asthma was not associated with several indicators of COVID-19 severity, including hospitalization, admission to an intensive care unit, mechanical ventilation, death due to COVID-19, and in-hospital mortality after multivariate adjustment. Patients with COVID-19 with asthma exhibited significantly lower levels of plasma interleukin-8 than patients without asthma (adjusted P = .02).

CONCLUSION:

The population with asthma is facing a challenge in preliminary COVID-19 evaluation owing to an overlap in the symptoms of COVID-19 and asthma. However, asthma does not increase the risk of COVID-19 severity if infected.
Subject(s)

Full text: Available Collection: International databases Database: MEDLINE Main subject: Asthma / Coinfection / COVID-19 Type of study: Cohort study / Diagnostic study / Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Topics: Long Covid Limits: Adult / Female / Humans / Male / Middle aged Language: English Journal: Ann Allergy Asthma Immunol Journal subject: Allergy and Immunology Year: 2021 Document Type: Article

Similar

MEDLINE

...
LILACS

LIS


Full text: Available Collection: International databases Database: MEDLINE Main subject: Asthma / Coinfection / COVID-19 Type of study: Cohort study / Diagnostic study / Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Topics: Long Covid Limits: Adult / Female / Humans / Male / Middle aged Language: English Journal: Ann Allergy Asthma Immunol Journal subject: Allergy and Immunology Year: 2021 Document Type: Article