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Association between self-reported signs and symptoms and SARS-CoV-2 antibody detection in UK key workers.
Mulchandani, Ranya; Taylor-Philips, Sian; Jones, Hayley E; Ades, A E; Borrow, Ray; Linley, Ezra; Kirwan, Peter D; Stewart, Richard; Moore, Philippa; Boyes, John; Hormis, Anil; Todd, Neil; Colda, Antoanela; Reckless, Ian; Brooks, Tim; Charlett, Andre; Hickman, Matthew; Oliver, Isabel; Wyllie, David.
  • Mulchandani R; UK Field Epidemiology Training Programme (FETP), Public Health England, London, United Kingdom; Field Service, Midlands, National Infection Service, Public Health England, Birmingham, United Kingdom.
  • Taylor-Philips S; Warwick Medical School, University of Warwick, Warwick, United Kingdom.
  • Jones HE; Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, United Kingdom; NIHR Health Protection Research Unit (HPRU) in Behavioural Science and Evaluation, University of Bristol, Bristol, United Kingdom.
  • Ades AE; Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, United Kingdom; NIHR Health Protection Research Unit (HPRU) in Behavioural Science and Evaluation, University of Bristol, Bristol, United Kingdom.
  • Borrow R; Seroepidemiology Unit (SEU), Manchester Royal Infirmary, Public Health England, Manchester, United Kingdom.
  • Linley E; Seroepidemiology Unit (SEU), Manchester Royal Infirmary, Public Health England, Manchester, United Kingdom.
  • Kirwan PD; Medical Research Council Biostatistics Unit, School of Clinical Medicine, University of Cambridge, Cambridge, United Kingdom.
  • Stewart R; Milton Keynes University Hospital NHS Foundation Trust, Milton Keynes, United Kingdom.
  • Moore P; Gloucestershire Hospitals NHS Foundation Trust, Gloucester, United Kingdom.
  • Boyes J; Gloucestershire Hospitals NHS Foundation Trust, Gloucester, United Kingdom.
  • Hormis A; The Rotherham NHS Foundation Trust, Rotherham, United Kingdom.
  • Todd N; York Teaching Hospital NHS Foundation Trust, York, United Kingdom.
  • Colda A; Milton Keynes University Hospital NHS Foundation Trust, Milton Keynes, United Kingdom.
  • Reckless I; Milton Keynes University Hospital NHS Foundation Trust, Milton Keynes, United Kingdom.
  • Brooks T; Rare and Imported Pathogens Laboratory (RIPL), Porton Down, Public Health England, Salisbury, United Kingdom.
  • Charlett A; Statistical Unit, Public Health England, London, United Kingdom.
  • Hickman M; Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, United Kingdom; NIHR Health Protection Research Unit (HPRU) in Behavioural Science and Evaluation, University of Bristol, Bristol, United Kingdom.
  • Oliver I; NIHR Health Protection Research Unit (HPRU) in Behavioural Science and Evaluation, University of Bristol, Bristol, United Kingdom; National Infection Service, Public Health England, Bristol, United Kingdom.
  • Wyllie D; Field Service, East of England, National Infection Service, Public Health England, Cambridge, United Kingdom; NIHR Health Protection Research Unit (HPRU) in Genomics and Data Enabling, University of Warwick, Warwick, United Kingdom. Electronic address: david.wyllie@phe.gov.uk.
J Infect ; 82(5): 151-161, 2021 05.
Article in English | MEDLINE | ID: covidwho-1155535
ABSTRACT

BACKGROUND:

Screening for SARS-CoV-2 antibodies is under way in some key worker groups; how this adds to self-reported COVID-19 illness is unclear. In this study, we investigate the association between self-reported belief of COVID-19 illness and seropositivity.

METHODS:

Cross-sectional study of three key worker streams comprising (A) Police and Fire & Rescue (2 sites) (B) healthcare workers (1 site) and (C) healthcare workers with previously positive PCR result (5 sites). We collected self-reported signs and symptoms of COVID-19 and compared this with serology results from two SARS-CoV-2 immunoassays (Roche Elecsys® and EUROIMMUN).

RESULTS:

Between 01 and 26 June, we recruited 2847 individuals (Stream A 1,247, Stream B 1,546 and Stream C 154). Amongst those without previous positive PCR tests, 687/2,579 (26%) reported belief they had COVID-19, having experienced compatible symptoms; however, only 208 (30.3%) of these were seropositive on both immunoassays. Both immunoassays had high sensitivities relative to previous PCR positivity (>93%); there was also limited decline in antibody titres up to 110 days post symptom onset. Symptomatic but seronegative individuals had differing symptom profiles and shorter illnesses than seropositive individuals.

CONCLUSION:

Non-COVID-19 respiratory illness may have been mistaken for COVID-19 during the outbreak; laboratory testing is more specific than self-reported key worker beliefs in ascertaining past COVID-19 disease.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: SARS-CoV-2 / COVID-19 Type of study: Diagnostic study / Experimental Studies / Observational study / Randomized controlled trials Limits: Humans Country/Region as subject: Europa Language: English Journal: J Infect Year: 2021 Document Type: Article Affiliation country: J.jinf.2021.03.019

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Full text: Available Collection: International databases Database: MEDLINE Main subject: SARS-CoV-2 / COVID-19 Type of study: Diagnostic study / Experimental Studies / Observational study / Randomized controlled trials Limits: Humans Country/Region as subject: Europa Language: English Journal: J Infect Year: 2021 Document Type: Article Affiliation country: J.jinf.2021.03.019