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Persistent Immune Activation in Human Immunodeficiency Virus-Infected Pregnant Women Starting Combination Antiretroviral Therapy After Conception.
Lohman-Payne, Barbara; Koster, Jacob; Gabriel, Benjamin; Chilengi, Roma; Forman, Leah S; Heeren, Tim; Duffy, Cassandra R; Herlihy, Julie; Crimaldi, Steven; Gill, Chris; Chavuma, Roy; Mwananyanda, Lawrence; Thea, Donald M.
  • Lohman-Payne B; Institute for Immunology and Informatics, Department of Cell and Molecular Biology, University of Rhode Island, Providence, Rhode Island, USA.
  • Koster J; National Emerging Infectious Diseases Laboratories, Boston University Medical Campus, Boston, Massachusetts, USA.
  • Gabriel B; Institute for Immunology and Informatics, Department of Cell and Molecular Biology, University of Rhode Island, Providence, Rhode Island, USA.
  • Chilengi R; Center for Infectious Disease Research Zambia, Lusaka, Zambia.
  • Forman LS; Biostatistics and Epidemiology Data Analytics Center, Boston University School of Public Health, Boston, Massachusetts, USA.
  • Heeren T; Departments of Biostatistics, Boston, Massachusetts, USA.
  • Duffy CR; Department of Obstetrics and Gynecology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA.
  • Herlihy J; Department of Pediatrics, Boston, Massachusetts, USA.
  • Crimaldi S; Department of Global Health, Boston University School of Public Health, Boston, Massachusetts, USA.
  • Gill C; Department of Global Health, Boston University School of Public Health, Boston, Massachusetts, USA.
  • Chavuma R; Department of Surgery, School of Medicine, University of Zambia, Lusaka, Zambia.
  • Mwananyanda L; Right to Care-Zambia, Lusaka, Zambia.
  • Thea DM; Department of Global Health, Boston University School of Public Health, Boston, Massachusetts, USA.
J Infect Dis ; 225(7): 1162-1167, 2022 04 01.
Article in English | MEDLINE | ID: covidwho-1155787
ABSTRACT
This study evaluated the impact of human immunodeficiency virus (HIV) and combination antiretroviral therapy (cART) on immune activation during pregnancy in a Zambian cohort of HIV-exposed but uninfected children followed up from birth. Activated CD8+ T cells (CD38+ and HLA-DR+) were compared among HIV-uninfected (n = 95), cART experienced HIV-infected (n = 111), and cART-naive HIV-infected (n = 21) pregnant women. Immune activation was highest among HIV-infected/cART-naive women but decreased during pregnancy. Immune activation HIV-infected women who started cART during pregnancy was reduced but not to levels similar to those in HIV-uninfected women. The effects of elevated maternal immune activation in pregnancy on subsequent infant health and immunity remain to be determined.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: HIV Infections / Antiretroviral Therapy, Highly Active Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study Limits: Female / Humans / Infant / Infant, Newborn / Pregnancy Language: English Journal: J Infect Dis Year: 2022 Document Type: Article Affiliation country: Infdis

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Full text: Available Collection: International databases Database: MEDLINE Main subject: HIV Infections / Antiretroviral Therapy, Highly Active Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study Limits: Female / Humans / Infant / Infant, Newborn / Pregnancy Language: English Journal: J Infect Dis Year: 2022 Document Type: Article Affiliation country: Infdis