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Thin-Section Chest CT Imaging of COVID-19 Pneumonia: A Comparison Between Patients with Mild and Severe Disease.
Yu, Minhua; Xu, Dan; Lan, Lan; Tu, Mengqi; Liao, Rufang; Cai, Shuhan; Cao, Yiyuan; Xu, Liying; Liao, Meiyan; Zhang, Xiaochun; Xiao, Shu-Yuan; Li, Yirong; Xu, Haibo.
  • Yu M; Departments of Radiology (M.Y., D.X., L.L., M.T., R.L., Y.C., L.X., M.L., X.Z., H.X.), Critical Care Medicine (S.C.), Pathology (S.Y.X.), and Laboratory Medicine (Y.L.), Zhongnan Hospital of Wuhan University, Wuchang District, Wuhan 430071, China; and Department of Pathology, University of Chicago M
  • Xu D; Departments of Radiology (M.Y., D.X., L.L., M.T., R.L., Y.C., L.X., M.L., X.Z., H.X.), Critical Care Medicine (S.C.), Pathology (S.Y.X.), and Laboratory Medicine (Y.L.), Zhongnan Hospital of Wuhan University, Wuchang District, Wuhan 430071, China; and Department of Pathology, University of Chicago M
  • Lan L; Departments of Radiology (M.Y., D.X., L.L., M.T., R.L., Y.C., L.X., M.L., X.Z., H.X.), Critical Care Medicine (S.C.), Pathology (S.Y.X.), and Laboratory Medicine (Y.L.), Zhongnan Hospital of Wuhan University, Wuchang District, Wuhan 430071, China; and Department of Pathology, University of Chicago M
  • Tu M; Departments of Radiology (M.Y., D.X., L.L., M.T., R.L., Y.C., L.X., M.L., X.Z., H.X.), Critical Care Medicine (S.C.), Pathology (S.Y.X.), and Laboratory Medicine (Y.L.), Zhongnan Hospital of Wuhan University, Wuchang District, Wuhan 430071, China; and Department of Pathology, University of Chicago M
  • Liao R; Departments of Radiology (M.Y., D.X., L.L., M.T., R.L., Y.C., L.X., M.L., X.Z., H.X.), Critical Care Medicine (S.C.), Pathology (S.Y.X.), and Laboratory Medicine (Y.L.), Zhongnan Hospital of Wuhan University, Wuchang District, Wuhan 430071, China; and Department of Pathology, University of Chicago M
  • Cai S; Departments of Radiology (M.Y., D.X., L.L., M.T., R.L., Y.C., L.X., M.L., X.Z., H.X.), Critical Care Medicine (S.C.), Pathology (S.Y.X.), and Laboratory Medicine (Y.L.), Zhongnan Hospital of Wuhan University, Wuchang District, Wuhan 430071, China; and Department of Pathology, University of Chicago M
  • Cao Y; Departments of Radiology (M.Y., D.X., L.L., M.T., R.L., Y.C., L.X., M.L., X.Z., H.X.), Critical Care Medicine (S.C.), Pathology (S.Y.X.), and Laboratory Medicine (Y.L.), Zhongnan Hospital of Wuhan University, Wuchang District, Wuhan 430071, China; and Department of Pathology, University of Chicago M
  • Xu L; Departments of Radiology (M.Y., D.X., L.L., M.T., R.L., Y.C., L.X., M.L., X.Z., H.X.), Critical Care Medicine (S.C.), Pathology (S.Y.X.), and Laboratory Medicine (Y.L.), Zhongnan Hospital of Wuhan University, Wuchang District, Wuhan 430071, China; and Department of Pathology, University of Chicago M
  • Liao M; Departments of Radiology (M.Y., D.X., L.L., M.T., R.L., Y.C., L.X., M.L., X.Z., H.X.), Critical Care Medicine (S.C.), Pathology (S.Y.X.), and Laboratory Medicine (Y.L.), Zhongnan Hospital of Wuhan University, Wuchang District, Wuhan 430071, China; and Department of Pathology, University of Chicago M
  • Zhang X; Departments of Radiology (M.Y., D.X., L.L., M.T., R.L., Y.C., L.X., M.L., X.Z., H.X.), Critical Care Medicine (S.C.), Pathology (S.Y.X.), and Laboratory Medicine (Y.L.), Zhongnan Hospital of Wuhan University, Wuchang District, Wuhan 430071, China; and Department of Pathology, University of Chicago M
  • Xiao SY; Departments of Radiology (M.Y., D.X., L.L., M.T., R.L., Y.C., L.X., M.L., X.Z., H.X.), Critical Care Medicine (S.C.), Pathology (S.Y.X.), and Laboratory Medicine (Y.L.), Zhongnan Hospital of Wuhan University, Wuchang District, Wuhan 430071, China; and Department of Pathology, University of Chicago M
  • Li Y; Departments of Radiology (M.Y., D.X., L.L., M.T., R.L., Y.C., L.X., M.L., X.Z., H.X.), Critical Care Medicine (S.C.), Pathology (S.Y.X.), and Laboratory Medicine (Y.L.), Zhongnan Hospital of Wuhan University, Wuchang District, Wuhan 430071, China; and Department of Pathology, University of Chicago M
  • Xu H; Departments of Radiology (M.Y., D.X., L.L., M.T., R.L., Y.C., L.X., M.L., X.Z., H.X.), Critical Care Medicine (S.C.), Pathology (S.Y.X.), and Laboratory Medicine (Y.L.), Zhongnan Hospital of Wuhan University, Wuchang District, Wuhan 430071, China; and Department of Pathology, University of Chicago M
Radiol Cardiothorac Imaging ; 2(2): e200126, 2020 Apr.
Article in English | MEDLINE | ID: covidwho-1155978
Semantic information from SemMedBD (by NLM)
1. Chest CT USES Microtomy
Subject
Chest CT
Predicate
USES
Object
Microtomy
2. Severe disease PROCESS_OF Patients
Subject
Severe disease
Predicate
PROCESS_OF
Object
Patients
3. Epidermal cGVHD Score 2 PROCESS_OF Patients
Subject
Epidermal cGVHD Score 2
Predicate
PROCESS_OF
Object
Patients
4. Pneumonia PROCESS_OF Patients
Subject
Pneumonia
Predicate
PROCESS_OF
Object
Patients
5. Contrast bronchogram USES air
Subject
Contrast bronchogram
Predicate
USES
Object
air
6. Ground Glass Opacity COEXISTS_WITH Pneumonia
Subject
Ground Glass Opacity
Predicate
COEXISTS_WITH
Object
Pneumonia
7. Parenchyma PART_OF Lung
Subject
Parenchyma
Predicate
PART_OF
Object
Lung
8. Mild disease PROCESS_OF Patients
Subject
Mild disease
Predicate
PROCESS_OF
Object
Patients
9. Contrast bronchogram DIAGNOSES COVID-19
Subject
Contrast bronchogram
Predicate
DIAGNOSES
Object
COVID-19
10. Chest CT USES Microtomy
Subject
Chest CT
Predicate
USES
Object
Microtomy
11. Severe disease PROCESS_OF Patients
Subject
Severe disease
Predicate
PROCESS_OF
Object
Patients
12. Epidermal cGVHD Score 2 PROCESS_OF Patients
Subject
Epidermal cGVHD Score 2
Predicate
PROCESS_OF
Object
Patients
13. Pneumonia PROCESS_OF Patients
Subject
Pneumonia
Predicate
PROCESS_OF
Object
Patients
14. Contrast bronchogram USES air
Subject
Contrast bronchogram
Predicate
USES
Object
air
15. Ground Glass Opacity COEXISTS_WITH Pneumonia
Subject
Ground Glass Opacity
Predicate
COEXISTS_WITH
Object
Pneumonia
16. Parenchyma PART_OF Lung
Subject
Parenchyma
Predicate
PART_OF
Object
Lung
17. Mild disease PROCESS_OF Patients
Subject
Mild disease
Predicate
PROCESS_OF
Object
Patients
18. Contrast bronchogram DIAGNOSES COVID-19
Subject
Contrast bronchogram
Predicate
DIAGNOSES
Object
COVID-19
ABSTRACT

PURPOSE:

To compare radiologic characteristics of coronavirus disease 2019 (COVID-19) pneumonia at thin-section CT on admission between patients with mild and severe disease. MATERIALS AND

METHODS:

Seventy patients with COVID-19 pneumonia who were admitted to Zhongnan Hospital of Wuhan University between January 20, 2020 and January 27, 2020 were enrolled. On the basis of the World Health Organization guidelines, 50 patients were categorized with the mild form and 20 with the severe form based on clinical conditions. Imaging features, clinical, and laboratory data were reviewed and compared.

RESULTS:

Patients with the severe form (median age, 65 years; interquartile range [IQR] 54.75-75.00 years) were older than those with the mild form of disease (median age, 42.5 years; IQR 32.75-58.50 years) (P < .001). Patients with the severe form of disease had more lung segments involved (median number of segments 17.5 vs 7.5, P ≤ .001) and also larger opacities (median number of segments with opacities measuring 3 cm to less than 50% of the lung segment 5.5 vs 2.0, P = .006; ≥ 50% of lung segment 7.5 vs 0.0, P < .001). They also had more interlobular septal thickening (75% vs 28%, P < .001), higher prevalence of air bronchograms (70% vs 32%, P = .004), and pleural effusions (40% vs 14%, P = .017).

CONCLUSION:

Ground-glass opacities with or without consolidation in a peripheral and basilar predominant distribution were the most common findings in COVID-19 pneumonia. Patients with the severe form of the disease had more extensive opacification of the lung parenchyma than did patients with mild disease. Interlobular septal thickening, air bronchograms, and pleural effusions were also more prevalent in severe COVID-19.© RSNA, 2020.

Full text: Available Collection: International databases Database: MEDLINE Type of study: Observational study / Prognostic study Language: English Journal: Radiol Cardiothorac Imaging Year: 2020 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Observational study / Prognostic study Language: English Journal: Radiol Cardiothorac Imaging Year: 2020 Document Type: Article