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Autoimmune and Rheumatic Manifestations Associated With COVID-19 in Adults: An Updated Systematic Review.
Tang, Kuo-Tung; Hsu, Bo-Chueh; Chen, Der-Yuan.
  • Tang KT; Division of Allergy, Immunology, and Rheumatology, Taichung Veterans General Hospital, Taichung, Taiwan.
  • Hsu BC; Faculty of Medicine, National Yang-Ming University, Taipei, Taiwan.
  • Chen DY; Ph.D. Program in Translational Medicine and Rong Hsing Research Center for Translational Medicine, National Chung Hsing University, Taichung, Taiwan.
Front Immunol ; 12: 645013, 2021.
Article in English | MEDLINE | ID: covidwho-1156124
ABSTRACT

Background:

Numerous cases of the coronavirus disease 2019 (COVID-19) with autoimmune and rheumatic manifestations have been reported. Despite the available reviews that summarized its autoimmune/rheumatic manifestations, a systematic approach is still lacking. Therefore, we conducted a comprehensive systematic review in order to give an overview upon these rare but clinically significant manifestations.

Methods:

We performed a literature search of PubMed and EMBASE as of October 9, 2020. All articles relevant to either systemic or organ-specific autoimmune and rheumatic manifestations potentially associated with COVID-19 were collected. The reviewed literature were limited to adults ≥18 years.

Results:

Although most of the existing evidence was based on case reports or case series without a long-term follow-up, a variety of autoimmune/rheumatic manifestations were associated with COVID-19. The manifestations that have a consistent association with COVID-19 include autoimmune cytopenia, cutaneous vasculitis, encephalitis, and Guillain-Barre syndrome. Such association is conflicting as regards to antiphospholipid syndrome, hemophagocytic lymphohistiocytosis, and myasthenia gravis.

Conclusion:

Our systematic review indicated the potential of the COVID-19 virus to trigger a myriad of autoimmune and rheumatic manifestations, which should be considered amid global efforts to combat COVID-19.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Autoimmune Diseases / Autoimmunity / Rheumatic Diseases / SARS-CoV-2 / COVID-19 Type of study: Cohort study / Diagnostic study / Observational study / Prognostic study / Reviews / Systematic review/Meta Analysis Topics: Long Covid Limits: Adolescent / Adult / Aged / Child / Child, preschool / Female / Humans / Male / Middle aged / Young adult Language: English Journal: Front Immunol Year: 2021 Document Type: Article Affiliation country: Fimmu.2021.645013

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Autoimmune Diseases / Autoimmunity / Rheumatic Diseases / SARS-CoV-2 / COVID-19 Type of study: Cohort study / Diagnostic study / Observational study / Prognostic study / Reviews / Systematic review/Meta Analysis Topics: Long Covid Limits: Adolescent / Adult / Aged / Child / Child, preschool / Female / Humans / Male / Middle aged / Young adult Language: English Journal: Front Immunol Year: 2021 Document Type: Article Affiliation country: Fimmu.2021.645013