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Optical Coherence Tomography Angiography Features in Post-COVID-19 Pneumonia Patients: A Pilot Study.
Cennamo, Gilda; Reibaldi, Michele; Montorio, Daniela; D'Andrea, Luca; Fallico, Matteo; Triassi, Maria.
  • Cennamo G; From the Department of Public Health, University of Naples "Federico II," Naples, Italy. Electronic address: xgilda@hotmail.com.
  • Reibaldi M; Department of Surgical Sciences, University of Torino, Torino, Italy.
  • Montorio D; Department of Neurosciences, Reproductive Sciences and Dentistry, University of Naples "Federico II", Naples, Italy.
  • D'Andrea L; Department of Neurosciences, Reproductive Sciences and Dentistry, University of Naples "Federico II", Naples, Italy.
  • Fallico M; Department of Ophthalmology, University of Catania, Catania, Italy.
  • Triassi M; From the Department of Public Health, University of Naples "Federico II," Naples, Italy.
Am J Ophthalmol ; 227: 182-190, 2021 07.
Article in English | MEDLINE | ID: covidwho-1157088
Semantic information from SemMedBD (by NLM)
1. Pneumonia caused by SARS-CoV-2 PROCESS_OF Patients
Subject
Pneumonia caused by SARS-CoV-2
Predicate
PROCESS_OF
Object
Patients
2. Pneumonia PROCESS_OF Patients
Subject
Pneumonia
Predicate
PROCESS_OF
Object
Patients
3. Eye PART_OF Patients
Subject
Eye
Predicate
PART_OF
Object
Patients
4. COVID-19 PROCESS_OF Patients
Subject
COVID-19
Predicate
PROCESS_OF
Object
Patients
5. Capillary vessel LOCATION_OF Decreased density
Subject
Capillary vessel
Predicate
LOCATION_OF
Object
Decreased density
6. angiogram DIAGNOSES retinal vascular
Subject
angiogram
Predicate
DIAGNOSES
Object
retinal vascular
7. Pneumonia caused by SARS-CoV-2 PROCESS_OF Patients
Subject
Pneumonia caused by SARS-CoV-2
Predicate
PROCESS_OF
Object
Patients
8. Pneumonia PROCESS_OF Patients
Subject
Pneumonia
Predicate
PROCESS_OF
Object
Patients
9. Eye PART_OF Patients
Subject
Eye
Predicate
PART_OF
Object
Patients
10. COVID-19 PROCESS_OF Patients
Subject
COVID-19
Predicate
PROCESS_OF
Object
Patients
11. Capillary vessel LOCATION_OF Decreased density
Subject
Capillary vessel
Predicate
LOCATION_OF
Object
Decreased density
12. angiogram DIAGNOSES retinal vascular
Subject
angiogram
Predicate
DIAGNOSES
Object
retinal vascular
ABSTRACT

PURPOSE:

This study investigated changes in retinal vessel density in macular and papillary regions in post-SARS-CoV-2 pneumonia patients by means of optical coherence tomography angiography (OCTA).

DESIGN:

Prospective, observational, cohort study.

METHODS:

Forty eyes of 40 patients (mean age 49.7 ± 12.6 years old) post-SARS-CoV-2 infection and 40 healthy subjects were enrolled in this study. COVID-19 patients had to be fully recovered from COVID-19 pneumonia and were evaluated 6 months after COVID-19 infection. The primary outcome resulted from OCTA studies of the following vascular structures vessel density (VD) in the retinal superficial capillary plexus (SCP), deep capillary plexus (DCP), and radial peripapillary capillaries (RPC) compared to those of controls. Structural spectral domain (SD)-OCT parameters were also evaluated ganglion cell complex (GCC) and retinal nerve fiber layer (RNFL).

RESULTS:

The patients showed a significant reduction in VD of the SCP in whole images and in the DCP in all sectors compared to those in healthy subjects (P <.05). COVID-19 patients featured a reduced VD of the RPC compared to that in controls (P <.001). No differences were found in the GCC, whereas the RNFL was reduced in the COVID-19 group compared to that in controls (P = .012). Significant correlations were found between the RNFL and VD of the SCP, DCP, RPC, and FAZ area in the COVID-19 group (P <.05).

CONCLUSIONS:

OCTA showed retinal vascular changes in subjects fully recovered from COVID-19 pneumonia. These findings could be a consequence of a thrombotic microangiopathy that affected retinal structures as well as other systemic organs. OCTA could represent a valid, noninvasive biomarker of early vascular dysfunction after SARS-CoV-2 infection.
Subject(s)

Full text: Available Collection: International databases Database: MEDLINE Main subject: Retinal Diseases / Retinal Vessels / Fluorescein Angiography / Tomography, Optical Coherence / COVID-19 / Macula Lutea Type of study: Observational study / Risk factors Topics: Long Covid Limits: Female / Humans / Male / Middle aged Language: English Journal: Am J Ophthalmol Year: 2021 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Retinal Diseases / Retinal Vessels / Fluorescein Angiography / Tomography, Optical Coherence / COVID-19 / Macula Lutea Type of study: Observational study / Risk factors Topics: Long Covid Limits: Female / Humans / Male / Middle aged Language: English Journal: Am J Ophthalmol Year: 2021 Document Type: Article