Your browser doesn't support javascript.
Role of phytoconstituents in the management of COVID-19.
Das, Amiya; Pandita, Deepti; Jain, Gaurav Kumar; Agarwal, Pallavi; Grewal, Ajmer Singh; Khar, Roop K; Lather, Viney.
  • Das A; Amity Institute of Molecular Medicine & Stem Cell Research (AIMMSCR), Amity University Uttar Pradesh, Sector-125, Noida, 201313, India.
  • Pandita D; Department of Pharmaceutics, Delhi Pharmaceutical Sciences and Research University, Pushp Vihar, New Delhi, 110017, India. Electronic address: deeptipandita@yahoo.co.uk.
  • Jain GK; Department of Pharmaceutics, Delhi Pharmaceutical Sciences and Research University, Pushp Vihar, New Delhi, 110017, India.
  • Agarwal P; Amity Institute of Molecular Medicine & Stem Cell Research (AIMMSCR), Amity University Uttar Pradesh, Sector-125, Noida, 201313, India.
  • Grewal AS; Guru Gobind Singh College of Pharmacy, Yamunanagar, Haryana, India.
  • Khar RK; BS Anangpuria Institute of Pharmacy, Faridabad, Haryana, India.
  • Lather V; Amity Institute of Pharmacy, Amity University Uttar Pradesh, Sector-125, Noida, 201313, India. Electronic address: vinnylather@gmail.com.
Chem Biol Interact ; 341: 109449, 2021 May 25.
Article in English | MEDLINE | ID: covidwho-1157165
Semantic information from SemMedBD (by NLM)
1. 2019 novel coronavirus CAUSES COVID-19
Subject
2019 novel coronavirus
Predicate
CAUSES
Object
COVID-19
2. Metabolite compared_with inhibitors
Subject
Metabolite
Predicate
compared_with
Object
inhibitors
3. Metabolite same_as inhibitors
Subject
Metabolite
Predicate
same_as
Object
inhibitors
4. Metabolite DISRUPTS Virus Internalization
Subject
Metabolite
Predicate
DISRUPTS
Object
Virus Internalization
5. treatment options COEXISTS_WITH COVID-19
Subject
treatment options
Predicate
COEXISTS_WITH
Object
COVID-19
6. COVID-19 drug treatment TREATS Virus Diseases
Subject
COVID-19 drug treatment
Predicate
TREATS
Object
Virus Diseases
7. 2019 novel coronavirus CAUSES COVID-19
Subject
2019 novel coronavirus
Predicate
CAUSES
Object
COVID-19
8. Metabolite compared_with inhibitors
Subject
Metabolite
Predicate
compared_with
Object
inhibitors
9. Metabolite same_as inhibitors
Subject
Metabolite
Predicate
same_as
Object
inhibitors
10. Metabolite DISRUPTS Virus Internalization
Subject
Metabolite
Predicate
DISRUPTS
Object
Virus Internalization
11. treatment options COEXISTS_WITH COVID-19
Subject
treatment options
Predicate
COEXISTS_WITH
Object
COVID-19
12. COVID-19 drug treatment TREATS Virus Diseases
Subject
COVID-19 drug treatment
Predicate
TREATS
Object
Virus Diseases
ABSTRACT

BACKGROUND:

COVID-19, a severe global pandemic caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has emerged as one of the most threatening transmissible disease. As a great threat to global public health, the development of treatment options has become vital, and a rush to find a cure has mobilized researchers globally from all areas. SCOPE AND

APPROACH:

This review focuses on deciphering the potential of different secondary metabolites from medicinal plants as therapeutic options either as inhibitors of therapeutic targets of SARS-CoV-2 or as blockers of viral particles entry through host cell receptors. The use of medicinal plants containing specific phytomoieties could be seen in providing a safer and long-term solution for the population with lesser side effects. Key Findings and

Conclusions:

Considering the high cost and time-consuming drug discovery process, therapeutic repositioning of existing drugs was explored as treatment option in COVID-19, however several molecules have been retracted as therapeutics either due to no positive outcomes or the severe side effects. These effects call for exploring the alternate treatment options which are therapeutically effective as well as safe. Keeping this in mind, phytopharmaceuticals derived from medicinal plants could be explored as important resources in the development of COVID-19 treatment, as their role in the past for treatment of viral diseases like HIV, MERS-CoV, and influenza has been well reported. Considering this fact, different phytoconstituents such as flavonoids, alkaloids, tannins and glycosides etc. Possessing antiviral properties against coronaviruses and possessing potential against SARS-CoV-2 have been reviewed in the present work.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: Antiviral Agents / Phytochemicals / COVID-19 Topics: Traditional medicine Limits: Humans Language: English Journal: Chem Biol Interact Year: 2021 Document Type: Article Affiliation country: J.cbi.2021.109449

Similar

MEDLINE

...
LILACS

LIS


Full text: Available Collection: International databases Database: MEDLINE Main subject: Antiviral Agents / Phytochemicals / COVID-19 Topics: Traditional medicine Limits: Humans Language: English Journal: Chem Biol Interact Year: 2021 Document Type: Article Affiliation country: J.cbi.2021.109449