Your browser doesn't support javascript.
Outcome of COVID-19 in hospitalized patients with chronic inflammatory diseases. A population based national register study in Denmark.
Kjeldsen, Jens; Nielsen, Jan; Ellingsen, Torkell; Knudsen, Torben; Nielsen, Rasmus Gaardskær; Larsen, Michael Due; Lund, Ken; Nørgård, Bente Mertz.
  • Kjeldsen J; Department of Medical Gastroenterology S, Odense University Hospital, Odense, Denmark; Research Unit of Medical Gastroenterology, Department of Clinical Research, University of Southern Denmark, Odense, Denmark. Electronic address: jens.kjeldsen@rsyd.dk.
  • Nielsen J; Center for Clinical Epidemiology, Odense University Hospital, Odense, Denmark; Research Unit of Clinical Epidemiology, Department of Clinical Research, University of Southern Denmark, Odense, Denmark.
  • Ellingsen T; Rheumatology Research Unit, Department of Rheumatology, Odense University Hospital and University of Southern Denmark, Odense, Denmark.
  • Knudsen T; Department of Medicine, Hospital of Southwest Jutland, Esbjerg, Denmark; Department of Regional Health Science, Centre Southwest Jutland, University of Southern Denmark, Esbjerg, Denmark.
  • Nielsen RG; Hans Christian Andersen Children's Hospital, Odense University Hospital, Odense, Denmark; Research Unit of Pediatrics, Department of Clinical Research, University of Southern Denmark, Odense, Denmark.
  • Larsen MD; Center for Clinical Epidemiology, Odense University Hospital, Odense, Denmark; Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway.
  • Lund K; Center for Clinical Epidemiology, Odense University Hospital, Odense, Denmark; Research Unit of Clinical Epidemiology, Department of Clinical Research, University of Southern Denmark, Odense, Denmark.
  • Nørgård BM; Center for Clinical Epidemiology, Odense University Hospital, Odense, Denmark; Research Unit of Clinical Epidemiology, Department of Clinical Research, University of Southern Denmark, Odense, Denmark.
J Autoimmun ; 120: 102632, 2021 06.
Article in English | MEDLINE | ID: covidwho-1157454
ABSTRACT

OBJECTIVE:

COVID-19 has substantial morbidity and mortality. We studied whether hospitalized patients with COVID-19 and chronic inflammatory diseases experienced worse outcomes compared to patients hospitalized with COVID-19 without chronic inflammatory diseases.

METHODS:

Danish nationwide registers were used to establish a cohort of hospitalized patients with COVID-19 and inflammatory bowel diseases (IBD), rheumatoid arthritis (RA), spondyloarthropathy (SpA), or psoriatic arthritis (PsA) (exposed), and a control cohort without these diseases (unexposed) between March 1, 2020, and October 31, 2020. We compared median length of hospital stay, used median regression models to estimate crude and adjusted differences. When estimating crude and adjusted odds ratio (OR) for continuous positive airway pressure (CPAP) and mechanical ventilation, in-hospital death, 14-day and 30-day mortality, we used logistic regression models.

RESULTS:

We identified 132 patients with COVID-19 and IBD, RA, SpA, or PsA, and 2811 unexposed admitted to hospital with COVID-19. There were no differences between exposed and unexposed regarding length of hospital stay (6.8 days vs. 5.5 days), need for mechanical ventilation (7.6% vs. 9.4%), or CPAP (11.4% vs. 8.8%). Adjusted OR for in-hospital death was 0.71 (95% CI 0.42-1.22), death after 14-days 0.70 (95% CI 0.42-1.16), and death after 30-days 0.68 (95% CI 0.41-1.13).

CONCLUSION:

Hospitalized patients with COVID-19 and chronic inflammatory diseases did not have statistically significant increased length of hospital stay, had same need for mechanical ventilation, and CPAP. Mortality was similar in hospitalized patients with COVID-19 and chronic inflammatory diseases, compared to patients hospitalized with COVID-19 and no chronic inflammatory diseases.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: Autoimmune Diseases / Registries / Hospital Mortality / SARS-CoV-2 / COVID-19 / Length of Stay Type of study: Cohort study / Observational study / Prognostic study Topics: Long Covid Limits: Aged / Female / Humans / Male / Middle aged Country/Region as subject: Europa Language: English Journal: J Autoimmun Journal subject: Allergy and Immunology Year: 2021 Document Type: Article

Similar

MEDLINE

...
LILACS

LIS


Full text: Available Collection: International databases Database: MEDLINE Main subject: Autoimmune Diseases / Registries / Hospital Mortality / SARS-CoV-2 / COVID-19 / Length of Stay Type of study: Cohort study / Observational study / Prognostic study Topics: Long Covid Limits: Aged / Female / Humans / Male / Middle aged Country/Region as subject: Europa Language: English Journal: J Autoimmun Journal subject: Allergy and Immunology Year: 2021 Document Type: Article